KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing
Open accessAbstract
Several studies have linked the KIBRA rs17070145 T polymorphism to superior episodic memory in healthy humans. One study investigated the effect of KIBRA on brain activation patterns (Papassotiropoulos et al., 2006) and observed increased hippocampal activation in noncarriers of the T allele during retrieval. Noncarriers were interpreted to need more hippocampal activation to reach the same performance level as T carriers. Using large behavioral (N= 2230) and fMRI (N= 83) samples, we replicated the KIBRA effect on episodic memory performance, but found increased hippocampal activation in T carriers during episodic retrieval. There was no evidence of compensatory brain activation in noncarriers within the hippocampal region. In the main fMRI sample, T carriers performed better than noncarriers during scanning but, importantly, the difference in hippocampus activation remained after post hoc matching according to performance, sex, and age (N= 64). These findings link enhanced memory performance in KIBRA T allele carriers to elevated hippocampal functioning, rather than to neural compensation in noncarriers.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
KIBRA interacts with several postsynaptic proteins including dendrin and synaptopodin and functions in memory-related processes through these interactions.
“It interacts with several postsynaptic proteins including dendrin and synaptopodin and function in memory-related processes through these interactions [75].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [75]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 34 · Cited by 81
Research works printed but not linked: 1
- Sacktor TC (2008) PKMz, LTP maintenance, and the dynamic molecular biology of memory storage. In: Progress in brain research 169 (Sossin WS, LAcaille JC, Castellucci VF, Belleville S, eds), pp 27-40. Amsterdam: Elsevier.
- Authors
- Kauppi, K., Nilsson, L.-G., Adolfsson, R., Eriksson, E., & Nyberg, L.
- Affiliations
- Umeå University (SE)
- Stockholm University (SE)
- University of Gothenburg (SE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-10-05
- Volume
- 31
- Issue
- 40
- Pages
- 14218-14222
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6623644
- OpenAlex
- W2008865593
- Cited by
- 81
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 6
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Swedish Brain Power
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- KIBRA, T allele, episodic memory, hippocampal activation, memory retrieval, genetic polymorphism, neural compensation, brain-behavior relationship
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alleles, Female, Genetic Carrier Screening, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Phosphoproteins, Psychomotor Performance, Polymorphism, Single Nucleotide, Intracellular Signaling Peptides and Proteins, Memory, Episodic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
