Shared versus Specialized Glycinergic Spinal Interneurons in Axial Motor Circuits of Larval Zebrafish
Open accessAbstract
The neuronal networks in spinal cord can produce a diverse array of motor behaviors. In aquatic vertebrates such as fishes and tadpoles, these include escape behaviors, swimming across a range of speeds, and struggling. We addressed the question of whether these behaviors are accomplished by a shared set of spinal interneurons activated in different patterns or, instead, involve specialized spinal interneurons that may shape the motor output to produce particular behaviors. We used larval zebrafish because they are capable of several distinct axial motor behaviors using a common periphery and a relatively small set of spinal neurons, easing the task of exploring the extent to which cell types are specialized for particular motor patterns. We performed targeted in vivo whole-cell patch recordings in 3 d post fertilization larvae to reveal the activity pattern of four commissural glycinergic interneuron types during escape, swimming and struggling behaviors. While some neuronal classes were shared among different motor patterns, we found others that were active only during a single one. These specialized neurons had morphological and functional properties consistent with a role in shaping key features of the motor behavior in which they were active. Our results, in combination with other evidence from excitatory interneurons, support the idea that patterns of activity in a core network of shared spinal neurons may be shaped by more specialized interneurons to produce an assortment of motor behaviors.
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Commissural inhibitory CoBL neurons (including dI6 and V0d populations) are active during swimming.
“Commissural inhibitory CoBL neurons (including neurons from the dI6 and V0d populations) are active during swimming (Liao and Fetcho, 2008; Satou et al., 2020).”
From Modeling spinal locomotor circuits for movements in developing zebrafish (2021) · cites this paper as Liao and Fetcho, 2008
The Results section on CoBL activity reports that all recorded CoBLs fired during at least some swimming episodes; it also describes their axons crossing the spinal cord. The Discussion treats CoBLs as glycinergic interneurons. Our copy does not identify the recorded CoBLs as belonging to the dI6 or V0d populations, so it does not support that part of the attribution. (LLM, conf=0.87)
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Research works printed but not linked: 33
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- Authors
- Liao, J. C., & Fetcho, J. R.
- Affiliations
- Cornell University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-26
- Volume
- 28
- Issue
- 48
- Pages
- 12982-12992
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2677998
- OpenAlex
- W1973256379
- Cited by
- 149
- References
- 36
- Citations by year
- 2025: 9 · 2024: 1 · 2023: 12 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 16 · 2013: 8 · 2012: 6
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS26539, R37NS026539, R01NS026539)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- glycinergic interneurons, spinal cord, commissural interneurons, motor behavior, escape behavior, swimming, zebrafish larvae, motor pattern generation, neural activity patterns, spinal motor circuits
- MeSH terms
- Action Potentials, Animals, Efferent Pathways, Glycine, Interneurons, Larva, Locomotion, Motor Neurons, Nerve Net, Neural Inhibition, Synaptic Transmission, Spinal Cord, Swimming, Synapses, Zebrafish, Patch-Clamp Techniques, Muscle, Skeletal
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