New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function
Open accessAbstract
BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and protein, and secretion and extracellular conversion of proBDNF to mature BDNF. Defects in these mechanisms contribute differentially to cognitive dysfunction and anxiety-like behaviors. Here we review recent studies, presented at a symposium at Neuroscience 2009, that describe regulatory mechanisms that permit rapid and dynamic refinement of BDNF actions in neurons.
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Growth factors and associated neurotrophic signaling play an essential role in the development and maintenance of the central nervous system.
“Growth factors and associated neurotrophic signaling play an essential role in the development and maintenance of the central nervous system (Anlar et al. 1999; Ford-Perriss et al. 2001; Greenberg et al. 2009).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Greenberg et al. 2009
BDNF has well-established actions in brain development and plasticity.
“BDNF has well-established actions in brain development and plasticity [116] .”
From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [116]
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References 28 · Cited by 597
- Authors
- Greenberg, M. E., Xu, B., Lu, B., & Hempstead, B. L.
- Affiliations
- Harvard University (US)
- Georgetown University (US)
- National Institutes of Health (US)
- Cornell University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-10-14
- Volume
- 29
- Issue
- 41
- Pages
- 12764-12767
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3091387
- OpenAlex
- W2033045687
- Cited by
- 597
- References
- 28
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 32 · 2023: 27 · 2022: 31 · 2021: 30 · 2020: 43 · 2019: 30 · 2018: 41 · 2017: 42 · 2016: 47 · 2015: 29 · 2014: 52 · 2013: 42 · 2012: 42
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James N. Kirby Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS050596, R01NS064114, R01NS030687, R21NS066235)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, BDNF secretion, dendritic targeting, neuronal activity regulation, synaptic plasticity, neuronal development, cognitive impairment, anxiety-like behavior
- MeSH terms
- Animals, Central Nervous System, Gene Expression Regulation, Neuronal Plasticity, Neurons, Brain-Derived Neurotrophic Factor, Protein Transport
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