The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Diffusion Tensor Imaging Reliably Detects Experimental Traumatic Axonal Injury and Indicates Approximate Time of Injury
Open accessAbstract
Traumatic axonal injury (TAI) may contribute greatly to neurological impairments after traumatic brain injury, but it is difficult to assess with conventional imaging. We quantitatively compared diffusion tensor imaging (DTI) signal abnormalities with histological and electron microscopic characteristics of pericontusional TAI in a mouse model. Two DTI parameters, relative anisotropy and axial diffusivity, were significantly reduced 6 h to 4 d after trauma, corresponding to relatively isolated axonal injury. One to 4 weeks after trauma, relative anisotropy remained decreased, whereas axial diffusivity “pseudo-normalized” and radial diffusivity increased. These changes corresponded to demyelination, edema, and persistent axonal injury. At every time point, DTI was more sensitive to injury than conventional magnetic resonance imaging, and relative anisotropy distinguished injured from control mice with no overlap between groups. Remarkably, DTI changes strongly predicted the approximate time since trauma. These results provide an important validation of DTI for pericontusional TAI and suggest novel clinical and forensic applications.
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Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738
KOCHANEK, P. M., MARION, D. W., ZHANG, W., SCHIDING, J. K., WHITE, M., PALMER, A. M., CLARK, R. S. B., O'MALLEY, M. E., STYREN, S. D., HO, C., et al. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.1015 · Cited by 203 · cited 1×
“…(Arfanakis et al., 2002; Naganawa et al., 2004; Voss et al., 2006) and none of the previous experimental animal studies (Hanstock et al., 1994; Kochanek et al., 1995; Alsop et al., 1996; Assaf et al., 1997; Albensi et al., 2000; Duhaime et al., 2003; Van Putten et al., 2005), to our…”
ResultSong, S.-K., Kim, J. H., Lin, S.-J., Brendza, R. P., & Holtzman, D. M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.003 · Cited by 170
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Cited by
The New Neurometabolic Cascade of Concussion
Giza, C. C., & Hovda, D. A. (2014) · Neurosurgery · doi:10.1227/neu.0000000000000505 · Cited by 1,353
Inflammation after trauma: Microglial activation and traumatic brain injury
Ramlackhansingh, A. F., Brooks, D. J., Greenwood, R. J., Bose, S. K., Turkheimer, F. E., Kinnunen, K. M., Gentleman, S., Heckemann, R. A., Gunanayagam, K., Gelosa, G., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22455 · Cited by 999
Salience network integrity predicts default mode network function after traumatic brain injury
Bonnelle, V., Ham, T. E., Leech, R., Kinnunen, K. M., Mehta, M. A., Greenwood, R. J., & Sharp, D. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113455109 · Cited by 606
Detection of Blast-Related Traumatic Brain Injury in U.S. Military Personnel
Mac Donald, C. L., Johnson, A. M., Cooper, D., Nelson, E. C., Werner, N. J., Shimony, J. S., Snyder, A. Z., Raichle, M. E., Witherow, J. R., Fang, R., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008069 · Cited by 599
Self-citationThe molecular pathophysiology of concussive brain injury
Barkhoudarian, G., Hovda, D. A., & Giza, C. C. (2011) · Clinics in Sports Medicine · doi:10.1016/j.csm.2010.09.001 · Cited by 492
Metadata
- Authors
- Mac Donald, C. L., Dikranian, K., Bayly, P., Holtzman, D., & Brody, D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-10-31
- Volume
- 27
- Issue
- 44
- Pages
- 11869-11876
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2083249651
- Cited by
- 435
- References
- 3
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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