The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Respiratory Rhythm Entrainment by Somatic Afferent Stimulation
Open accessAbstract
Respiratory and locomotor patterns are coupled during locomotion. The objectives of this study were to (1) demonstrate that respiratory rhythms are entrained by sensory input from somatic afferents, (2) establish whether the parabrachial nucleus mediates entrainment, (3) examine responses of single respiratory neurons in the ventral respiratory group (VRG) to somatic afferent stimulation, and (4) use a computational model of the pontomedullary respiratory network (Rybak et al., 2004a,b) to suggest neuronal mechanisms for entrainment. We used an in situ preparation in young rats that retained pontomedullary respiratory circuits and spinal pathways transmitting somatosensory input. We demonstrate that rhythmic stimulation of somatic afferents entrains respiratory rhythm on a 1:1 basis (1:1), increasing breathing frequency up to ∼1.4-2.2 times greater than spontaneous frequency. Stable entrainment occurred only when stimuli were delivered during expiration. Reversible blockade of the lateral parabrachial nucleus eliminated entrainment. Somatic afferent stimulation produced significant increases in the firing rate of augmenting expiratory (E2) neurons but shortened the firing duration of postinspiratory (post-I) neurons. A computational model reproduced 1:1 entrainment and other experimental findings based on the assumption that the somatic afferents initiate early onset of inspiration via activation of medullary E2 neurons. The model also predicted that afferent stimulation evoked transient hyperpolarization of ramp-inspiratory (ramp-I) neurons. This was confirmed experimentally by intracellular recording from ramp-I neurons. Our experimental and modeling results demonstrate that an entrainment pathway from somatic afferents to the VRG via the lateral parabrachial nucleus causes resetting of respiratory rhythm through excitation of E2 and consequent inhibition of post-I neurons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Somatic afferent stimulation contributes to this entrainment, which can be prevented by blockade of the PB nucleus (cf Daley and Usherwood 2010; Porterfield 1985; Potts et al. 2005).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Potts et al. 2005
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reflex cardiovascular and respiratory responses originating in exercising muscle
McCloskey, D. I., & Mitchell, J. H. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009887 · Cited by 1,105
Bianchi, A. L., Denavit‐Saubié, M., & Champagnat, J. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.1 · Cited by 922
The regulation of respiration and circulation during the initial stages of muscular work
Krogh, A., & Lindhard, J. (1913) · The Journal of Physiology · doi:10.1113/jphysiol.1913.sp001616 · Cited by 891
Running and Breathing in Mammals
Bramble, D. M., & Carrier, D. R. (1983) · Science · doi:10.1126/science.6849136 · Cited by 567
Neurogenesis of respiratory rhythm in the mammal
Cohen, M. I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.1105 · Cited by 538
Observations on the respiratory centres in the cat
Lumsden, T. (1923) · The Journal of Physiology · doi:10.1113/jphysiol.1923.sp002052 · Cited by 435
Dempsey, J. A., & Pack, A. I. (1994) · M. Dekker eBooks · Cited by 423
Exercise Hyperpnea and Locomotion: Parallel Activation from the Hypothalamus
Eldridge, F. L., Millhorn, D. E., & Waldrop, T. G. (1981) · Science · doi:10.1126/science.7466362 · Cited by 417
Spinal and trigeminal dorsal horn projections to the parabrachial nucleus in the rat
Cechetto, D. F., Standaert, D. G., & Saper, C. B. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902400205 · Cited by 406
Neurophysiology of Breathing in Mammals
Feldman, J. L. (1986) · Comprehensive physiology · doi:10.1002/cphy.cp010409 · Cited by 405
Research works printed but not linked: 14
- 1994, J Neurosci, 4, 6500
- 1977, Fed Proc, 36, 2367
- 1967, Circ Res, 20-21, I146
- 1992, Passive wing flapping. J Appl Physiol, 73, 1014
- 1893, Scand Arch Physiol, 5, 20
- 1986, Acta Physiol Scand, 259, 1
- 1977, Am J Physiol, 233, H374
- 1991, J Auton Nerv Syst, 21, 195
- 1986, Am J Physiol, 263, R962
- 2000, Soc Neurosci Abstr, 26, 546
- 2001, Soc Neurosci Abstr, 27, 173
- 2002, FASEB J, 16, A809
- 1986, News Physiol Sci, 1, 109
- 1997, Models of respiratory neurons. J Neurophysiol, 77, 1994
Cited by
Sorted by citations
Items 101–128 of 128
Neuromodulatory Support for Breathing and Cardiovascular Action During Development
Harper, R. M., & Kesavan, K. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.753215 · Cited by 4
Fujita, M., Kamibayashi, K., Aoki, T., Horiuchi, M., & Fukuoka, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.820666 · Cited by 4
Respiratory resetting elicited by single pulse spinal stimulation
Sunshine, M. D., Ganji, C. N., Fuller, D. D., & Moritz, C. T. (2019) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2019.103339 · Cited by 4
Classifying reverse triggering breaths: A clinically oriented approach
Gallardo, A., Sayat, M., Silvero, A., & Silveira, J. M. N. (2025) · Journal of Mechanical Ventilation · doi:10.53097/jmv.10141 · Cited by 3
Korim, W. S., Egwuenu, E. J., Fong, A. Y., McMullan, S., Cravo, S. L. D., & Pilowsky, P. M. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.066365 · Cited by 3
Pyatin, V. F., Tatarnikov, V. S., & Glazkova, E. N. (2007) · Neurophysiology · doi:10.1007/s11062-008-9009-4 · Cited by 3
Flor, K. C., Maia, O. A. D. C., Takakura, A. C. T., & Moreira, T. S. (2024) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00155.2024 · Cited by 3
Critique of ‘Control of arterial PCO2 by somatic afferents’
Yu, Y., & Poon, C. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.572.301 · Cited by 3
The Double-edged Sword of Reverse Triggering: Impact on the Diaphragm
Sassoon, C. S., & Mancebo, J. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202201-0099ed · Cited by 3
Effect of cadence on respiratory response during unloaded cycling in healthy individuals
Jastrzębska, A. D., & Kowalski, M. (2015) · Human Movement · doi:10.1515/humo-2015-0025 · Cited by 2
Atmung, Ventilation, Atembewegung
Beyer, L. (2006) · Manuelle Medizin · doi:10.1007/s00337-006-0482-9 · Cited by 2
Sauciuc, G.-A., Schneider, J. N., & Hattori, Y. (2026) · Fascinating life sciences · doi:10.1007/978-3-032-24250-1_9 · Cited by 2
Thoracic sympathetic chain stimulation modulates and entrains the respiratory pattern
Dhingra, R. R., Kola, G., Lewis, S. J., & Dutschmann, M. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.01.008 · Cited by 1
Genes and development of respiratory rhythm generation
Champagnat, J., Fortin, G., & Thoby‐Brisson, M. (2007) · Springer eBooks · doi:10.1007/978-0-387-70765-5_11
Power, G. A. (2008) · Memorial University Research Repository (Memorial University)
A latent serotonin-1A receptor-gated spinal afferent pathway inhibiting breathing
Yang, L., Song, G., Ning, Y., & Poon, C. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1155-z · Cited by 1
Alsahafi, Z. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r38c9rg5b
Piechatzek, L. A. (2007) · DuEPublico (University of Duisburg-Essen)
Neural Control of Respiration by the Retrotrapezoid Nucleus.
Basting, T. M. (2016) · doi:10.18130/v3mg60
Etat du corpus des IG d'Egypte et de Nubie
Bernard, E. (2002) · Zeitschrift für Papyrologie und Epigraphik
Tolmachev, P., Dhingra, R. R., Manton, J. H., & Dutschmann, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.04.442535
Shevtsova, N. A., Marchenko, V., Rybak, I. A., & Bezdudnaya, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.30.697059
Self-citationExperience-dependent modulation of prosocial touch in mice
Sun, Y., Hong, W., & Wu, Y. E. (2026) · iScience · doi:10.1016/j.isci.2026.115102
Correction of Patient–Ventilator Discordance
Davies, J. D., Pratt, E., & Rackley, C. R. (2026) · Respiratory Care · doi:10.1177/19433654261425215
Herrick, J. E. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/08zr-f665
運動―呼吸リズムが上肢エルゴメーター運動時の呼吸・換気応答に及ぼす影響
宮本, 俊., 玉木, 彰., & 森谷, 敏. (2012) · Journal of the Japanese Physical Therapy Association · doi:10.15063/rigaku.kj00008046834
Metadata
- Authors
- Potts, J. T., Rybak, I. A., & Paton, J. F. R.
- Affiliations
- Wayne State University (US)
- Drexel University (US)
- University of Bristol (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-02-23
- Volume
- 25
- Issue
- 8
- Pages
- 1965-1978
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6726065
- OpenAlex
- W1983775575
- Cited by
- 128
- References
- 75
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 11 · 2015: 8 · 2014: 5 · 2013: 1 · 2012: 11
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- Funders
- British Heart Foundation
- Children's Hospital of Michigan
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL059167, R01HL072415, HL072415-01, R01HL059167)
- National Institute of Neurological Disorders and Stroke (NS046062-2, R01NS046062)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Keywords
- somatosensory input, parabrachial nucleus, ventral respiratory group, expiratory neurons
- MeSH terms
- Afferent Pathways, Animals, Inhalation, Computer Simulation, Decerebrate State, Forelimb, Isonicotinic Acids, Locomotion, Microinjections, Models, Neurological, Muscle Contraction, Neurons, Phrenic Nerve, Respiratory Center, Respiratory Physiological Phenomena, Time Factors, Vagus Nerve, Patch-Clamp Techniques, Rats, GABA-A Receptor Agonists, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
