Inhibition of Kainate Receptors Reduces the Frequency of Hippocampal Theta Oscillations

Huxter, John R.; Zinyuk, Larissa E.; Roloff, Eva v. L.; Clarke, Vernon R. J.; Dolman, Nigel P.; More, Julia C. A.; Jane, David E.; Collingridge, Graham L.; Muller, Robert U.

doi:10.1523/jneurosci.3954-06.2007

Inhibition of Kainate Receptors Reduces the Frequency of Hippocampal Theta Oscillations

We investigated the role of kainate receptors in the generation of theta oscillations using ( S )-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophene-3-yl-methyl)pyrimidine-2,4-dione (UBP304), a novel, potent and highly selective antagonist of GLU K5 -containing kainate receptors. EEG and single-uni…