Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
Open accessAbstract
Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB 1 ) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.
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Fast-scanning cyclic voltammetry studies have shown an increased frequency of spontaneous phasic DA signals in the NAc in response to cannabinoids and nicotine in awake, behaving animals, and temporally distinct DA signals in response to cocaine.
“In addition, studies using fast-scanning cyclic voltammetry, which can detect the level of DA release in the intact brain on a timescale of seconds, have shown an increased frequency of spontaneous phasic DA signals in the NAc in response to cannabinoids and nicotine in awake, behaving animals [125,126], and also temporally distinct DA signals in response to cocaine [127].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [126]
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References 34 · Cited by 374
- Authors
- Cheer, J. F., Wassum, K. M., Sombers, L. A., Heien, M. L. A. V., Ariansen, J. L., Aragona, B. J., Phillips, P. E. M., & Wightman, R. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-01-24
- Volume
- 27
- Issue
- 4
- Pages
- 791-795
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672925
- OpenAlex
- W2157977435
- Cited by
- 374
- References
- 34
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 17 · 2020: 44 · 2019: 23 · 2018: 14 · 2017: 17 · 2016: 22 · 2015: 29 · 2014: 25 · 2013: 15 · 2012: 24
- FWCI
- 17.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA10900, R01DA010900)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine release, nucleus accumbens shell, drug-seeking behavior, nicotine, ethanol, cocaine, rimonabant, CB1 receptor, addiction treatment
- MeSH terms
- Rimonabant, Animals, Dopamine, Nucleus Accumbens, Piperidines, Pyrazoles, Illicit Drugs, Time Factors, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, Rats, Cannabinoid Receptor Modulators
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