Removal of Polysialic Acid Triggers Dispersion of Subventricularly Derived Neuroblasts into SurroundingCNS Tissues
Open accessAbstract
Cells generated in the subventricular zone give rise to neuroblasts that migrate to the olfactory bulb (OB) along the rostral migratory stream (RMS). The polysialylated form of neural cell adhesion molecule (PSA-NCAM) is expressed by these cells, and has been shown to both promote their migration and suppress differentiation induced by NCAM. In the present study, enzymatic removal of PSA from these neuroblasts using PSA-specific endoneuraminidase has been found not only to disrupt the tangential migration and cellular organization of the RMS, but also to cause a massive dispersion of BrdU (5-bromo-2′-deoxyuridine)-labeled neuroblasts into surrounding brain regions, including cortex and striatum. These dispersed cells are capable of differentiation, some into mature neurons, and could potentially be of value in the repair of CNS injury. Although the removal of PSA by genetic deletion of NCAM also results in a smaller OB and a swollen RMS, the cells do not escape the RMS in large numbers. These findings suggest that the presence of NCAM without PSA plays a role in the dispersion process, possibly by inducing a new pattern of migration associated with NCAM-dependent differentiation.
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The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.
“The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”
From Biological roles of glycans (2017) · cites this paper as [550]
The Introduction links polysialic acid to neuroblast migration, and the Discussion reports altered migration after its removal. The Discussion describes recruitment of progenitors to a lesion as a potential route to repair; it does not show that polysialic acid expression is important for reorganization following injury. The indexed passages provide no page numbers. (LLM, conf=0.84)
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References 45 · Cited by 60
- Authors
- Battista, D., & Rutishauser, U.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Rutishauser, Urs
- ORCID
- Rutishauser, Urs
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-17
- Volume
- 30
- Issue
- 11
- Pages
- 3995-4003
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632263
- OpenAlex
- W2134727307
- Cited by
- 60
- References
- 45
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 11 · 2012: 5
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- polysialic acid, CD56, PSA-NCAM, subventricular zone, rostral migratory stream, neuroblast migration, olfactory bulb, neuronal differentiation, CNS injury repair, tangential migration
- MeSH terms
- Animals, Brain, Bromodeoxyuridine, Cell Differentiation, Cell Movement, Cerebral Ventricles, Glycoside Hydrolases, Mice, Inbred BALB C, Neurons, Olfactory Bulb, Sialic Acids, Stem Cells, Mice, Knockout, Neural Cell Adhesion Molecules, Mice, Neurogenesis
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