Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

Cortical inhibitory neurons and schizophrenia

Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297

Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6

Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605

The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

Jentsch, J. D. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00060-8 · Cited by 1,329

NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons

Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

Kawasaki, Y., Zhang, L., Cheng, J.-K., & Ji, R.-R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3338-07.2008 · Cited by 1,162

NMDA receptor hypofunction model of schizophrenia

Olney, J. W., Newcomer, J. W., & Farber, N. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00029-1 · Cited by 1,020

Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002

Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia

Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938

Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase

Behrens, M. M., Ali, S. S., Dao, D. N., Lucero, J., Shekhtman, G., Quick, K. L., & Dugan, L. L. (2007) · Science · doi:10.1126/science.1148045 · Cited by 585

Naringin Confers Protection against Psychosocial Defeat Stress-Induced Neurobehavioral Deficits in Mice: Involvement of Glutamic Acid Decarboxylase Isoform-67, Oxido-Nitrergic Stress, and Neuroinflammatory Mechanisms

Oladapo, O. M., Ben‐Azu, B., Ajayi, A. M., Emokpae, O., Eneni, A.-E. O., Omogbiya, I. A., & Iwalewa, E. O. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01664-y · Cited by 51

Ketamine potentiates oxidative stress and influences behavior and inflammation in response to lipolysaccharide (LPS) exposure in early life

Réus, G. Z., Simões, L. R., Colpo, G. D., Scaini, G., Oses, J. P., Generoso, J. S., Prossin, A. R., Kaddurah‐Daouk, R., Quevedo, J., & Barichello, T. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.016 · Cited by 48

Altered Serum Tumor Necrosis Factor and Interleukin-1β in First-Episode Drug-Naive and Chronic Schizophrenia

Zhu, F., Zhang, L., Liu, F., Wu, R., Guo, W., Ou, J., Zhang, X., & Zhao, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00296 · Cited by 47

How Nox2-Containing NADPH Oxidase Affects Cortical Circuits in the NMDA Receptor Antagonist Model of Schizophrenia

Wang, X., Pinto-Duarte, A., Sejnowski, T. J., & Behrens, M. M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4907 · Cited by 46

Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia

O’Donnell, P. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08130.x · Cited by 47

Age‐dependent loss of parvalbumin‐expressing hippocampal interneurons in mice deficient in CHL 1, a mental retardation and schizophrenia susceptibility gene

Schmalbach, B., Lepsveridze, E., Djogo, N., Papashvili, G., Kuang, F., Leshchyns’ka, I., Sytnyk, V., Nikonenko, A. G., Dityatev, A. E., Jakovčevski, I., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13284 · Cited by 46

The NADPH oxidase NOX2 as a novel biomarker for suicidality: evidence from human post mortem brain samples

Schiavone, S., Neri, M., Mhillaj, E., Morgese, M. G., Cantatore, S., Bové, M., Riezzo, I., Tucci, P., Pomara, C., Turillazzi, E., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.76 · Cited by 45

Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase

Brown, C. O., Salem, K., Wagner, B. A., Bera, S., Singh, N., Tiwari, A., Choudhury, A., Buettner, G. R., & Goel, A. (2012) · Biochemical Journal · doi:10.1042/bj20112019 · Cited by 45

Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials

Marini, S., Berardis, D. D., Vellante, F., Santacroce, R., Orsolini, L., Valchera, A., Girinelli, G., Carano, A., Fornaro, M., Gambi, F., et al. (2016) · Mediators of Inflammation · doi:10.1155/2016/3476240 · Cited by 48

Prenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment

Allswede, D. M., & Cannon, T. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000317 · Cited by 46

Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex

Garcia-Oscos, F., Peña, D., Housini, M., Cheng, D., Lopez, D., Borland, M. S., Salgado-Delgado, R., Salgado, H., D’Mello, S., Kilgard, M. P., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.07.020 · Cited by 43

Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology

Catts, V. S., & Weickert, C. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035511 · Cited by 43

Impaired DNA Damage Repair as a Common Feature of Neurodegenerative Diseases and Psychiatric Disorders

Shiwaku, H., & Okazawa, H. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303002556 · Cited by 43

Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia

Morishita, H., Kundakovic, M., Bicks, L., Mitchell, A., & Akbarian, S. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.03.005 · Cited by 42

Elevated Viral Restriction Factor Levels in Cortical Blood Vessels in Schizophrenia

Siegel, B. I., Sengupta, E. J., Edelson, J. R., Lewis, D. A., & Volk, D. W. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.019 · Cited by 42

Chronic Ketamine Reduces the Peak Frequency of Gamma Oscillations in Mouse Prefrontal Cortex Ex vivo

McNally, J. M., McCarley, R. W., & Brown, R. E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00106 · Cited by 43

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2

Cheng, J., Edin, M. L., Hoopes, S. L., Li, H., Bradbury, J. A., Graves, J. P., DeGraff, L. M., Lih, F. B., Garcia, V. G., Shaik, J. S., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-241927 · Cited by 41

The role of immunoglobulin E and mast cells in hypertension

Ge, W., Guo, X., Song, X., Pang, J., Zou, X., Liu, Y., Niu, Y., Zheng-qing, L., Zhao, H., Gao, R., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac010 · Cited by 43

Perturbations in reward-related decision-making induced by reduced prefrontal cortical GABA transmission: Relevance for psychiatric disorders

Piantadosi, P. T., Khayambashi, S., Schluter, M. G., Kutarna, A., & Floresco, S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.007 · Cited by 40

EEG biomarkers of target engagement, therapeutic effect, and disease process

Featherstone, R. E., McMullen, M. F., Ward, K. R., Bang, J., Xiao, J., & Siegel, S. J. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12745 · Cited by 40

To re-examine the intersection of microglial activation and neuroinflammation in neurodegenerative diseases from the perspective of pyroptosis

Li, Y., Li, Y., & Zhu, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1284214 · Cited by 43

Dietary supplementation with N-acetyl cysteine, α-tocopherol and α-lipoic acid reduces the extent of oxidative stress and proinflammatory state in aged rat brain

Thakurta, I. G., Chattopadhyay, M., Ghosh, A., & Chakrabarti, S. (2012) · Biogerontology · doi:10.1007/s10522-012-9392-5 · Cited by 39

Neurobiology of Schizophrenia Onset

Woo, T.-U. W. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_243 · Cited by 46

GABA-BZD Receptor Modulating Mechanism of Panax quinquefolius against 72-h Sleep Deprivation Induced Anxiety like Behavior: Possible Roles of Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation

Chanana, P., & Kumar, A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00084 · Cited by 39

Vagus Nerve Stimulation: A Personalized Therapeutic Approach for Crohn’s and Other Inflammatory Bowel Diseases

Cirillo, G., Negrete-Diaz, F., Yucumá, D., Virtuoso, A., Korai, S. A., Luca, C. D., Kaniušas, E., Papa, M., & Panetsos, F. (2022) · Cells · doi:10.3390/cells11244103 · Cited by 40

Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions

Zhang, C., Jiang, H., Wang, P., Liu, H., & Sun, X. (2017) · Scientific Reports · doi:10.1038/srep44708 · Cited by 37

The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.

Liu, F., Havens, J. F., Yu, Q., Wang, G., Davisson, R. L., Pickel, V. M., & Iadecola, C. (2012) · Europe PMC (PubMed Central) · Cited by 37

Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus

Nomura, T., Oyamada, Y., Fernandes, H. B., Remmers, C. L., Xu, J., Meltzer, H. Y., & Contractor, A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.012 · Cited by 40

Neuroprotective effects of the ethanol stem bark extracts ofTerminalia ivorensisin ketamine-induced schizophrenia-like behaviors and oxidative damage in mice

Ben‐Azu, B., Aderibigbe, A. O., Ajayi, A. M., & Iwalewa, E. O. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1190382 · Cited by 38

Dysregulation of the axonal trafficking of nuclear‐encoded mitochondrial mRNA alters neuronal mitochondrial activity and mouse behavior

Kar, A. N., Sun, C., Reichard, K. L., Gervasi, N. M., Pickel, J. M., Nakazawa, K., Gioio, A. E., & Kaplan, B. B. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22141 · Cited by 36

Is (R)-ketamine a potential therapeutic agent for treatment-resistant depression with less detrimental side effects? A review of molecular mechanisms underlying ketamine and its enantiomers

Scotton, E., Antqueviezc, B., Vasconcelos, M., Dalpiaz, G., Géa, L. P., Goularte, J. F., Colombo, R., & Rosa, A. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114963 · Cited by 37

Distinct Mitochondria-Mediated T-Cell Apoptosis Responses in Children and Adults With Coronavirus Disease 2019

Yang, Y., Kuang, L., Li, L., Wu, Y., Zhong, B., & Huang, X. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab400 · Cited by 34

NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion

Murotomi, K., Takagi, N., Takeo, S., & Tanonaka, K. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.01.009 · Cited by 35

Do schizophrenia patients age early?

Shivakumar, V., Kalmady, S. V., Venkatasubramanian, G., Ravi, V., & Gangadhar, B. N. (2014) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2014.02.007 · Cited by 34

Pharmacological targeting of redox regulation systems as new therapeutic approach for psychiatric disorders: A literature overview

Schiavone, S., & Trabace, L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.019 · Cited by 36

Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice

Iwahara, N., Hisahara, S., Kawamata, J., Matsumura, A., Yokokawa, K., Saito, T., Fujikura, M., Manabe, T., Suzuki, H., Matsushita, T., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160887 · Cited by 34

Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200–CD200R and CX3CL1–CX3CR1 Systems

Chamera, K., Szuster-Głuszczak, M., Trojan, E., & Basta-Kaim, A. (2020) · Cells · doi:10.3390/cells9071676 · Cited by 31

Mouse pharmacological models of cognitive disruption relevant to schizophrenia

Young, J. W., Powell, S. B., & Geyer, M. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.013 · Cited by 33

Bench-to-bedside review: Neonatal sepsis - redox processes in pathogenesis

Spasojević, I., Obradović, B., & Spasić, S. D. (2012) · Critical Care · doi:10.1186/cc11183 · Cited by 32

Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice

Ali, S. S., Young, J. W., Wallace, C. K., Gresack, J. E., Jeste, D. V., Geyer, M. A., Dugan, L. L., & Risbrough, V. B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.009 · Cited by 32

Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse

Seredenina, T. S., Sorce, S., Herrmann, F. R., Mulone, X.-J. M., Plastre, O., Aguzzi, A., Jaquet, V., & Krause, K.-H. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.175 · Cited by 32

Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers

Benneyworth, M. A., Roseman, A. S., Basu, A. C., & Coyle, J. T. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.043 · Cited by 30

Reactive Oxygen Species-mediated Loss of Phenotype of Parvalbumin Interneurons Contributes to Long-term Cognitive Impairments After Repeated Neonatal Ketamine Exposures

Zhang, H., Sun, X., Wang, J., Zhang, Z., Zhao, H., Li, H., Ji, M., Li, K.-Y., & Yang, J. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9653-1 · Cited by 31

Can N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Be Localized to an Individual Cell Type?

Bygrave, A. M., Kilonzo, K., Kullmann, D. M., Bannerman, D. M., & Kätzel, D. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00835 · Cited by 35

Oxidative Stress, Neuroinflammation, and Neurodegeneration

Gao, H., Zhou, H., & Hong, J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_5 · Cited by 30

Diesel exhaust particles (DEP) induce an early redox imbalance followed by an IL-6 mediated inflammatory response on human conjunctival epithelial cells

Vitar, R. M. L., Tau, J., Janezic, N. S., Tesone, A. I., Arana, A. G. H., Reides, C. G., Berra, A., Ferreira, S. M., & Llesuy, S. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.03.005 · Cited by 29

Ketamine-Based Anesthetic Protocols and Evoked Potential Monitoring: A Risk/Benefit Overview

Stoicea, N., Versteeg, G. H., Florescu, D., Joseph, N. C., Fiorda‐Diaz, J., Navarrete, V., & Bergese, S. D. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00037 · Cited by 29

Towards a neurodynamical understanding of the prodrome in schizophrenia

Mikanmaa, E., Grent-‘t-Jong, T., Hua, L., Recasens, M., Thuné, H., & Uhlhaas, P. J. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.026 · Cited by 33

Recent advances in psychoneuroimmunology: Inflammation in psychiatric disorders

Debnath, M., Doyle, K., Langan, C., McDonald, C., Leonard, B., & Cannon, D. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0019-0 · Cited by 28

Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients

Sasayama, D., Wakabayashi, C., Hori, H., Teraishi, T., Hattori, K., Ota, M., Ishikawa, M., Arima, K., Higuchi, T., Amano, N., et al. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.06.003 · Cited by 28

Astrocytes as Pharmacological Targets in the Treatment of Schizophrenia

Pocivavsek, A., Notarangelo, F. M., Wu, H., Bruno, J. P., & Schwarcz, R. M. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00025-0 · Cited by 30

Current State of Biomarkers in Bipolar Disorder

Scola, G., & Andreazza, A. C. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0514-4 · Cited by 27

Molecular mechanisms involved in the prevention and reversal of ketamine-induced schizophrenia-like behavior by rutin: the role of glutamic acid decarboxylase isoform-67, cholinergic, Nox-2-oxidative stress pathways in mice

Oshodi, T. O., Ben‐Azu, B., Ishola, I. O., Ajayi, A. M., Emokpae, O., & Umukoro, S. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06264-6 · Cited by 26

Ginsenoside Re protects against phencyclidine-induced behavioral changes and mitochondrial dysfunction via interactive modulation of glutathione peroxidase-1 and NADPH oxidase in the dorsolateral cortex of mice

Tran, T.-V., Shin, E., Dang, D., Ko, S. K., Jeong, J. H., Nah, S.-Y., Jang, C., Lee, Y. J., Toriumi, K., Nabeshima, T., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.019 · Cited by 26

PPARγ provides anti-inflammatory and protective effects in intrahepatic cholestasis of pregnancy through NF-κB pathway

Zhang, Y., Huang, X., Zhou, J., Yin, Y., Zhang, T., & Chen, D. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.035 · Cited by 26

Impact of neuroinflammation on brain glutamate and dopamine signalling in schizophrenia: an update

Nayak, U. Y., Manikkath, J., Arora, D. S., & Mudgal, J. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01548-3 · Cited by 29

Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia

Chamera, K., Trojan, E., Kotarska, K., Szuster-Głuszczak, M., Bryniarska, N., Tylek, K., & Basta‐Kaim, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041558 · Cited by 25

Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound

Baazaoui, N., & Iqbal, K. (2022) · Biomolecules · doi:10.3390/biom12101409 · Cited by 27

Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease

Liu, H., Zhang, H., & Ma, Y. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111452 · Cited by 25

Role of IL-6 In The Etiology Of Hyperexcitable Neuropsychiatric Conditions: Experimental Evidence And Therapeutic Implications

Atzori, M., García‐Oscos, F., & Méndez, J. A. T. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.156 · Cited by 25

Pluripotent stem cells as a model to study oxygen metabolism in neurogenesis and neurodevelopmental disorders

Paulsen, B. D. S., Silveira, M. S., Galina, A., & Rehen, S. K. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.10.009 · Cited by 23

The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence

Ask, T. F., Lugo, R. G., & Sütterlin, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00726 · Cited by 23

Radioprotective Agents and Enhancers Factors. Preventive and Therapeutic Strategies for Oxidative Induced Radiotherapy Damages in Hematological Malignancies

Allegra, A. G., Mannino, F., Innao, V., Musolino, C., & Allegra, A. (2020) · Antioxidants · doi:10.3390/antiox9111116 · Cited by 22

Ketamine's schizophrenia-like effects are prevented by targeting PTP1B

Qin, Z., Zhang, L., ZASLOFF, M. A., Stewart, A. F. R., & Chen, H. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105397 · Cited by 25

Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers

Fan, N., Luo, Y., Xu, K., Zhang, M., Ke, X., Huang, X., Ding, Y., Wang, D., Ning, Y., Deng, X., et al. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.11.006 · Cited by 21

Early Celastrol Administration Prevents Ketamine-Induced Psychotic-Like Behavioral Dysfunctions, Oxidative Stress and IL-10 Reduction in The Cerebellum of Adult Mice

Schiavone, S., Tucci, P., Trabace, L., & Morgese, M. G. (2019) · Molecules · doi:10.3390/molecules24213993 · Cited by 20

Diosmin attenuates schizophrenia-like behavior, oxidative stress, and acetylcholinesterase activity in mice

Eneni, A.-E. O., Ben‐Azu, B., Ajayi, A. M., & Aderibigbe, A. O. (2020) · Drug metabolism and drug interactions · doi:10.1515/dmpt-2020-0119 · Cited by 20

Survival Response of Hippocampal Neurons under Low Oxygen Conditions Induced by Hippophae rhamnoides is Associated with JAK/STAT Signaling

Manickam, M., & Tulsawani, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087694 · Cited by 20

Intermittent Hypoxia-Induced Parvalbumin-Immunoreactive Interneurons Loss and Neurobehavioral Impairment is Mediated by NADPH-Oxidase-2

Yuan, L., Wu, J., Liu, J., Li, G., & Liang, D. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1586-1 · Cited by 20

The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review

Schiavone, S., Neri, M., Mhillaj, E., Pomara, C., Trabace, L., & Turillazzi, E. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.06.002 · Cited by 20

Systemic inflammation and cortical neurochemistry in never-medicated first episode-psychosis individuals

León-Ortíz, P., Rivera-Chávez, L. F., Torres-Ruiz, J. J., Reyes-Madrigal, F., Carrillo-Vázquez, D. A., Moncada-Habib, T., Cassiano-Quezada, F., Cadenhead, K. S., Gómez‐Martín, D., & de la Fuente‐Sandoval, C. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.05.001 · Cited by 19

Adolescent GBR12909 exposure induces oxidative stress, disrupts parvalbumin-positive interneurons, and leads to hyperactivity and impulsivity in adult mice

Khan, A., de Jong, L. A. W., Kamenski, M. E., Higa, K. K., Lucero, J. D., Young, J. W., Behrens, M. M., & Powell, S. B. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.022 · Cited by 19

Ketamine administration induces early and persistent neurochemical imbalance and altered NADPH oxidase in mice

Schiavone, S., Morgese, M. G., Bové, M., Colia, A. L., Maffione, A. B., Tucci, P., Trabace, L., & Cuomo, V. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109750 · Cited by 19

Parvalbumin-Deficiency Accelerates the Age-Dependent ROS Production in Pvalb Neurons in vivo: Link to Neurodevelopmental Disorders

Janickova, L., & Schwaller, B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.571216 · Cited by 19

Recent Reports on Redox Stress-Induced Mitochondrial DNA Variations, Neuroglial Interactions, and NMDA Receptor System in Pathophysiology of Schizophrenia

Beeraka, N. M., Ávila-Rodriguez, M., & Aliev, G. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02703-4 · Cited by 18

A review of potential neuropathological changes associated with ketamine

Nogo, D., Nazal, H., Song, Y., Teopiz, K. M., Ho, R., McIntyre, R. S., Lui, L. M. W., & Rosenblat, J. D. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2071867 · Cited by 21

A randomised double-blind placebo-controlled 12- week feasibility trial of methotrexate added to treatment as usual in early schizophrenia: study protocol for a randomised controlled trial

Chaudhry, I. B., Husain, N., Rahman, R.-U., Husain, M. O., Hamirani, M. M., Kazmi, A., Baig, S., Haddad, P. M., Buch, M. H., Qureshi, I., et al. (2015) · Trials · doi:10.1186/1745-6215-16-9 · Cited by 16

Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia

Zuccoli, G. S., Nascimento, J. M., Codo, A. C., Moraes-Vieira, P. M., Rehen, S. K., & Martins‐de‐Souza, D. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01605-x · Cited by 15

Neurocognitive, Neuroprotective, and Cardiometabolic Effects of Raloxifene: Potential for Improving Therapeutic Outcomes in Schizophrenia

Khan, M. M. (2016) · CNS Drugs · doi:10.1007/s40263-016-0343-6 · Cited by 15

Parvalbumin Loss Following Chronic Sub-Anesthetic NMDA Antagonist Treatment is Age-Dependent in the Hippocampus: Implications for Modeling NMDA Hypofunction

Honeycutt, J. A., & Chrobak, J. J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.031 · Cited by 15

Physiologically normal 5% O2 supports neuronal differentiation and resistance to inflammatory injury in neural stem cell cultures

Sun, X., Voloboueva, L. A., Stary, C. M., & Giffard, R. G. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23615 · Cited by 14

Psychedelic Therapy: A Primer for Primary Care Clinicians—Ketamine

Evans, V. D., Arenas, A., Shinozuka, K., Tabaac, B. J., Beutler, B. D., Cherian, K. N., Fasano, C., & Muir, O. S. (2024) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001721 · Cited by 19

Influence of Cyclooxygenase-2 Inhibitors on Kynurenic Acid Production in Rat Brain in Vitro

Zakrocka, I. N., Targowska‐Duda, K. M., Wnorowski, A., Kocki, T., Jóźwiak, K., & Turski, W. A. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9952-9 · Cited by 13

Pathway-specific contribution of parvalbumin interneuron NMDARs to synaptic currents and thalamocortical feedforward inhibition

Lewis, E. M., Spence, H. E., Akella, N., & Buonanno, A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01747-9 · Cited by 14

Mast cell stabilizer, an anti-allergic drug, reduces ventricular arrhythmia risk via modulation of neuroimmune interaction

Wang, Y., Liu, Z., Zhou, W., Wang, J., Li, R., Peng, C., Jiao, L., Zhang, S., Liu, Z., Yu, Z., et al. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-023-01024-y · Cited by 12

Transcriptional Activation, Deactivation and Rebound Patterns in Cortex, Hippocampus and Amygdala in Response to Ketamine Infusion in Rats

Kim, J., Sapio, M. R., Vazquez, F. A., Maric, D., Loydpierson, A. J., Ma, W., Zarate, C. A., Iadarola, M. J., & Mannes, A. J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.892345 · Cited by 14

In Vitro and In Vivo Effects of Ketamine on Generation and Function of Dendritic Cells

Zeng, J., Xia, S.-X., Zhong, W., Li, J., & Lin, L. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11113fp · Cited by 12

Effects of Current Psychotropic Drugs on Inflammation and Immune System

Bhatt, S., Dhar, A. K., Samanta, M. K., & Suttee, A. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_18 · Cited by 12

Exploring the role of TNF-α, TGF-β, and IL-6 serum levels in categorical and noncategorical models of mood and psychosis

Pantović-Stefanović, M., Velimirović, M., Jurišić, V., Puric, M., Gostiljac, M., Dodić, S., Minic, I., Nesic, M. J., Nikolić, T., Petronijević, N., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-73937-0 · Cited by 13

The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders

Allami, P., Yazdanpanah, N., & Rezaei, N. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0153 · Cited by 11

Interleukin 6 trans-signaling regulates basal synaptic transmission and sensitivity to pentylenetetrazole-induced seizures in mice

Cuevas‐Olguin, R., Esquivel‐Rendon, E., Vargas‐Mireles, J., García‐Oscos, F., Miranda‐Morales, M., Salgado, H., Rose‐John, S., & Atzori, M. (2017) · Synapse · doi:10.1002/syn.21984 · Cited by 11

Activation of the Maternal Immune System as a Risk Factor for Neuropsychiatric Disorders

Smith, S. E. P., Hsiao, E. Y., & Patterson, P. H. (2010) · Springer eBooks · doi:10.1007/978-1-60327-921-5_7 · Cited by 12

Clozapine attenuates mitochondrial burdens and abnormal behaviors elicited by phencyclidine in mice via inhibition of p47 phox ; Possible involvements of phosphoinositide 3-kinase/Akt signaling

Tran, H., Park, S. J., Shin, E., Tran, T.-V., Sharma, N., Lee, Y. J., Jeong, J. H., Jang, C., Kim, D.-J., Nabeshima, T., et al. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118795244 · Cited by 9

Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex

Zou, Y., Zhang, H., Chen, X., Ji, W., Mao, L., & Lei, H. C. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104503 · Cited by 10

Robust Expression of Functional NMDA Receptors in Human Induced Pluripotent Stem Cell-Derived Neuronal Cultures Using an Accelerated Protocol

Ruden, J. B., Dixit, M., Zepeda, J. C., Grueter, B. A., & Dugan, L. L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.777049 · Cited by 10

Region-specific reduction of parvalbumin neurons and behavioral changes in adult mice following single exposure to cranial irradiation

Ueno, H., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1564081 · Cited by 9

Diosmin attenuates schizophrenia-like behavior, oxidative stress, and acetylcholinesterase activity in mice

Eneni, A.-E. O., Ben‐Azu, B., Ajayi, A. M., & Aderibigbe, A. O. (2020) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmdi-2020-0119 · Cited by 9

Inhibition of oxidative stress, neuroinflammatory cytokines, and protein expressions contributes to the antipsychotic effects of geraniol in mice with ketamine-induced schizophrenia

Uruaka, C. I., Ben‐Azu, B., Omeiza, N. A., Chidebe, E. O., Ajayi, A. M., Lemii, B. C., Nonju, T. I., Georgewill, U. O., & Georgewill, O. A. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10226-1 · Cited by 8

Neuroimmunological Aberrations and Cerebral Asymmetry Abnormalities in Schizophrenia: Select Perspectives on Pathogenesis

Venkatasubramanian, G., & Debnath, M. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.1.8 · Cited by 10

Development/Plasticity/Repair Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia

Behrens, M. M., Ali, S. S., & Dugan, L. L. (2015)

Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase

Behrens, M. M., Ali, S. S., Dao, D. N., Lucero, J., Shekhtman, G., Quick, K. L., & Dugan, L. L. (2007) · Science · doi:10.1126/science.1148045 · Cited by 585

Ketamine Findings Suggest Path to New Schizophrenia Drugs

Moran, M. (2008) · Psychiatric News · doi:10.1176/pn.43.2.0034

Drugs, Psychosis, and Schizophrenia

Stern, P. (2007) · Science s STKE · doi:10.1126/stke.4162007tw451

Acute ketamine induces neuronal hyperexcitability and deficits in prepulse inhibition by upregulating IL-6

Luo, Y., Yang, Y., He, H., & Fan, N. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110913 · Cited by 6