The Impact of Input Fluctuations on the Frequency–Current Relationships of Layer 5 Pyramidal Neurons in the Rat Medial Prefrontal Cortex
Open accessAbstract
The role of irregular cortical firing in neuronal computation is still debated, and it is unclear how signals carried by fluctuating synaptic potentials are decoded by downstream neurons. We examined in vitro frequency versus current (f–I) relationships of layer 5 (L5) pyramidal cells of the rat medial prefrontal cortex (mPFC) using fluctuating stimuli. Studies in the somatosensory cortex show that L5 neurons become insensitive to input fluctuations as input mean increases and that their f–I response becomes linear. In contrast, our results show that mPFC L5 pyramidal neurons retain an increased sensitivity to input fluctuations, whereas their sensitivity to the input mean diminishes to near zero. This implies that the discharge properties of L5 mPFC neurons are well suited to encode input fluctuations rather than input mean in their firing rates, with important consequences for information processing and stability of persistent activity at the network level.
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The sensitivity of individual neurons to synaptic fluctuations can vary with neural subtype or cortical area and with biophysical cellular properties, such as membrane capacitance and conductance.
“Furthermore, the sensitivity of individual neurons to synaptic fluctuations can vary with neural subtype or cortical area and with biophysical cellular properties, such as membrane capacitance and conductance89–93.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [89]
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References 75 · Cited by 75
- Authors
- Arsiero, M., Lüscher, H.-R., Lundstrom, B. N., & Giugliano, M.
- Affiliations
- University of Bern (CH)
- University of Washington (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-03-21
- Volume
- 27
- Issue
- 12
- Pages
- 3274-3284
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672485
- OpenAlex
- W2016672252
- Cited by
- 75
- References
- 75
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 7
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by-nc-sa)
- BORIS (University Library Bern) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- SDL (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Achievement Rewards for College Scientists Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (61335)
- U.S. Public Health Service (T32 07266)
- National Institute of General Medical Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › stochastic dynamics and bifurcation
- Keywords
- layer 5 pyramidal neurons, medial prefrontal cortex, frequency-current relationship, neuronal firing rate, persistent activity
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Nerve Net, Neurons, Rats, Wistar, Prefrontal Cortex, Rats
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