The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo
Open accessAbstract
Hearing impairment due to the loss of sensory hair cells is permanent in humans. Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with which to promote hair cell regeneration. We generated a novel mouse model to direct the expression of Atoh1 in a spatially and temporally specific manner in the postnatal mammalian cochlea to determine the competency of various types of cochlear epithelial cells for hair cell differentiation. Atoh1 can generate cells in young animals with morphological, molecular, and physiological properties reminiscent of hair cells. This competency is cell type specific and progressively restricted with age. Significantly, Atoh1 induces ectopic sensory patches through Notch signaling to form a cellular mosaic similar to the endogenous sensory epithelia and expansion of the sensory mosaic through the conversion of supporting cells and nonautonomous supporting cell production. Furthermore, Atoh1 also activates proliferation within the normally postmitotic cochlear epithelium. These results provide insight into the potential and limitations of Atoh1-mediated hair cell regeneration.
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Cites
Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497 · cited 1×
“6C,D), cultures treated with DAPT, which inhibits -secretase-dependent cleavage of Notch required for downstream signaling (Geling et al., 2002), had an ectopic sensory region made up almost entirely of MyoVI-positive hair cells with only a few nonsensory cells throughout (Fig.”
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Cited by
Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo
Cox, B. C., Chai, R., Lenoir, A., Liu, Z., Zhang, L., Nguyen, D.-H., Chalasani, K., Steigelman, K. A., Fang, J., Cheng, A. G., et al. (2014) · Development · doi:10.1242/dev.103036 · Cited by 285
Metadata
- Authors
- Kelly, M. C., Chang, Q., Pan, A., Lin, X., & Chen, P.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-05-09
- Volume
- 32
- Issue
- 19
- Pages
- 6699-6710
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2049903984
- Cited by
- 218
- References
- 1
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kelly, M. C., Chang, Q., Pan, A., Lin, X., & Chen, P. (2012). Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.5420-11.2012
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