Serotonin Induces Long-Term Depression at Corticostriatal Synapses
Open accessAbstract
The striatum has important roles in motor control and action learning and, like many brain regions, receives multiple monoaminergic inputs. We have examined serotonergic modulation of rat and mouse corticostriatal neurotransmission and find that serotonin (5-HT) activates 5-HT 1b receptors resulting in a long-term depression (LTD) of glutamate release and striatal output that we have termed 5-HT–LTD. 5-HT–LTD is presynaptically mediated, cAMP pathway dependent, and inducible by endogenous striatal 5-HT, as revealed by application of a selective 5-HT reuptake inhibitor. 5-HT–LTD is mutually occlusive with dopamine/endocannabinoid-dependent LTD, suggesting that these two forms of LTD act on the same corticostriatal terminals. Thus, serotonergic and dopaminergic mechanisms exist that may interact to persistently sculpt corticostriatal circuits, potentially influencing action learning and striatal-based disorders.
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Application of serotonin to slices of either the dorsal or ventral striatum causes a long-term depression of excitatory synaptic transmission via activation of presynaptic 5-HT1b receptors.
“Over a decade ago, application of 5-HT to slices of either the dorsal or ventral striatum was found to cause a long-term depression (LTD) of excitatory synaptic transmission via activation of presynaptic 5-HT1b receptors [64].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [64]
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References 27 · Cited by 114
- Authors
- Mathur, B. N., Capik, N. A., Alvarez, V. A., & Lovinger, D. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Lovinger, David M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-05-18
- Volume
- 31
- Issue
- 20
- Pages
- 7402-7411
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3113491
- OpenAlex
- W2019535443
- Cited by
- 114
- References
- 27
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 4 · 2015: 11 · 2014: 9 · 2013: 9 · 2012: 7
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000407, ZIAAA000416, ZIAAA000421)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- serotonin, long-term depression, corticostriatal synapses, 5-HT1B receptor, presynaptic modulation, glutamate release, cAMP signaling, 5-HT reuptake inhibitors, dopamine, endocannabinoid signaling, striatal output, action learning
- MeSH terms
- Animals, Cerebral Cortex, Corpus Striatum, Mice, Transgenic, Serotonin, Synapses, Rats, Sprague-Dawley, Long-Term Synaptic Depression, Receptor, Serotonin, 5-HT1B, Mice, Rats
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