Young microglia restore amyloid plaque clearance of aged microglia

Daria, Anna, Colombo, Alessio, Llovera, Gemma, Hampel, Heike, Willem, Michael, Liesz, Arthur, Haass, Christian, Tahirovic, Sabina·2017·The EMBO Journal

Cited by (176)

Items 101–176 of 176

  1. Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner
    Kelley T. Patten, Anthony E. Valenzuela, Christopher Wallis, Danielle Jenine Harvey, Keith J. Bein, Anthony S. Wexler, Fredric A. Gorin, Pamela J. Lein · 2022 · Frontiers in Cellular Neuroscience
  2. Space-Dependent Glia–Neuron Interplay in the Hippocampus of Transgenic Models of β-Amyloid Deposition
    Daniele Lana, Filippo Ugolini, Maria Grazia Giovannini · 2020 · International Journal of Molecular Sciences
  3. Differential Glial Response and Neurodegenerative Patterns in CA1, CA3, and DG Hippocampal Regions of 5XFAD Mice
    Tahsin Nairuz, Jin-Chul Heo, Jong‐Ha Lee · 2024 · International Journal of Molecular Sciences
  4. Mind the Gap: Unraveling the Intricate Dance Between Alzheimer’s Disease and Related Dementias and Bone Health
    Sonali Jayant Karnik, Tyler J. Margetts, Hannah S. Wang, Alexandru Movilă, Adrian L. Oblak, Jill C. Fehrenbacher, Melissa A. Kacena, Lilian Irene Plotkin · 2024 · Current Osteoporosis Reports
  5. Microglial Modulation in Alzheimer’s Disease: Central Players in Neuroinflammation and Pathogenesis
    Md Sadique Hussain, Yumna Khan, Rabab Fatima, Mudasir Maqbool, Prasanna Srinivasan Ramalingam, Mohammad Gayoor Khan, Ajay Singh Bisht · 2025 · Current Alzheimer Research
  6. POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research
    Hailey Pineau, Valerie L. Sim · 2020 · Biomolecules
  7. Gas6/TAM Signalling Negatively Regulates Inflammatory Induction of GM-CSF in Mouse Brain Microglia
    Shannon E. Gilchrist, Grace M. Pennelli, Sassan Hafizi · 2021 · Cells
  8. Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
    Susanna R. Var, Phoebe Strell, Sether T. Johnson, Alex Roman, Zoey Vasilakos, Walter C. Low · 2023 · Cell Transplantation
  9. Microglia play an important role in PRV infection-induced immune responses of the central nervous system
    Xiuxiu Sun, Xinxin Jin, Xi Liu, Lumeng Wang, Li Li, Junjie Yang, Helong Feng, Zhengdan Lin, Cunlin Zhan, Wanpo Zhang et al. · 2023 · Virology Journal
  10. Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review
    Vasileios Topalis, Charalampos Voros, Mairi Ziaka · 2025 · Journal of Geriatric Psychiatry and Neurology
  11. Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model
    Jasenka Rudan Njavro, Marija Vukicevic, Emma Fiorini, Lina Dinkel, Stephan A. Müller, Anna Berghofer, Chiara Bordier, Stanislav O. Kozlov, Annett Halle, Katrin Buschmann et al. · 2022 · Cells
  12. How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD
    YunHee Seol, Soomin Ki, Hannah L. Ryu, Sooyoung Chung, Jung-Hee Lee, Hoon Ryu · 2020 · Frontiers in Molecular Neuroscience
  13. Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer’s Disease
    Diana Reimers, Manuela Vallejo-Muñoz, Marı́a José Casarejos, Adriano Jiménez‐Escrig, Rafael Gonzalo‐Gobernado, Eulalia Bazán · 2021 · International Journal of Molecular Sciences
  14. Failure of Alzheimer’s Mice Brain Resident Neural Precursor Cells in Supporting Microglia-Mediated Amyloid β Clearance
    Marva Lachish, Nina Fainstein, Tal Ganz, Lihi Sofer, Tamir Ben‐Hur · 2022 · Cells
  15. Treadmill Exercise Promotes Microglial β-Amyloid Clearance and Prevents Cognitive Decline in APP/PS1 Mice
    Fei Liang, Feng Sun, Biao He, Jing Wang · 2022 · Neuroscience
  16. Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis
    Justin Torok, Chaitali Anand, Parul Verma, Ashish Raj · 2022 · Translational research
  17. Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets
    Mai M. Anwar, Leonor Pérez‐Martínez, Gustavo Pedraza‐Alva · 2024 · Immunological Investigations
  18. Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
    Alessio Vittorio Colombo, Lina Dinkel, Stephan A. Müller, Laura Sebastián Monasor, Martina Schifferer, Ludovico Cantuti‐Castelvetri, Jasmin König, Lea Vidatic, Tatiana Brémovà-Ertl, Silva Katusic Hecimovic et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Therapeutic approaches to microglial dysfunction in Alzheimer's disease: Enhancing phagocytosis and metabolic regulation
    Waleed Hassan Almalki, Salem Salman Almujri · 2024 · Pathology - Research and Practice
  20. Could immunotherapy and regulatory T cells be used therapeutically to slow the progression of Alzheimer’s disease?
    Victoria Abbott, Benjamin E. Housden, Annwyne Houldsworth · 2025 · Brain Communications
  21. Senescent microglia: The hidden culprits accelerating Alzheimer’s disease
    Wu Li, Yongyan Xie, Mu Jia-Xin, Ge Shu-Chao, Huang Li-Ping · 2025 · Brain Research
  22. The indispensability of macrophage adaptor proteins in chronic inflammatory diseases
    Rajat Atre, Rahul Sharma, Vadim Gaponenko, Kundan Solanki, Khandu Wadhonkar, Neha Singh, Pramod Patidar, Rakhi Khabiya, Harshita Samaur, Sreeparna Banerjee et al. · 2023 · International Immunopharmacology
  23. T he Improvement Effects of Sika Deer Antler Protein in an Alzheimer's Disease Mouse Model via the Microbe–Gut–Brain Axis
    Lei Li, Lulu Wang, Weixing Ding, Jianfa Wu, Fei Liu, Jiansong Liu, Jing Zhang, Jing Wang · 2024 · Food Science & Nutrition
  24. Crosstalk between the aging intestinal microflora and the brain in ischemic stroke
    Ryszard M. Pluta, Mirosław Jabłoński, Sławomir Januszewski, Stanisław Jerzy Czuczwar · 2022 · Frontiers in Aging Neuroscience
  25. The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis.
    L. Hoeijmakers, G. Meerhoff, Janneke W. de Vries, S. Ruigrok, A. van Dam, F. Van Leuven, A. Korosi, P. Lucassen · 2018 · Neurobiology of Aging
  26. Inflammation in Alzheimer's Disease, and Prevention with Antioxidants and Phenolic Compounds – What Are the Most Promising Candidates?
    Matthew J. Sharman, Giuseppe Verdile, Shanmugam Kirubakaran, Gerald W Münch · 2019 · Wiley eBooks
  27. Searching for the cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer’s disease
    Justin Torok, Pedro D. Maia, Chaitali Anand, Ashish Raj · 2025 · Communications Biology
  28. Dulaglutide Alleviates Alzheimer's Disease by Regulating Microglial Polarization and Neurogenic Activity
    Yun Wang, Bojun Han · 2022 · Combinatorial Chemistry & High Throughput Screening
  29. Microbial and immune factors regulate brain maintenance and aging
    Laetitia Travier, Roshani Singh, Daniel Sáenz Fernández, Aleksandra Deczkowska · 2022 · Current Opinion in Neurobiology
  30. Minocycline augmentation in older adults with persistent depression: an open label proof of concept study
    Jimmy Avari, Dora Kanellopoulos, Nili Solomonov, Lauren E. Oberlin, George S. Alexopoulos · 2020 · International Psychogeriatrics
  31. Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States
    Madison K. Kuhn, Elizabeth A. Proctor · 2024 · Proteins Structure Function and Bioinformatics
  32. Prevention of Alzheimer Pathology by Blocking Neuregulin Signaling on Microglia
    Jianguo Liu, Joseph R. Geraghty, Sarah Schram, Haley C. Cropper, Justin Lei, Jeffrey A. Loeb, Fei Song · 2023 · eNeuro
  33. Reestablishing microglia function: good news for Alzheimer's therapy?
    Biber, Knut · 2017 · The EMBO Journal
  34. Effects of Intravenously Administered Plasma from Exercise-Trained Donors on Microglia and Cytokines in a Transgenic Rat Model of Alzheimer’s Disease
    Aleksi M. Huuha, Cecilie Skarstad Norevik, Jeff Scott Coombes, Ragnhild N. Røsbjørgen, Rodrigo Miguel‐dos‐Santos, José Bianco Nascimento Moreira, Asgeir Kobro‐Flatmoen, Nathan Robert Scrimgeour, Atefe R. Tari · 2024 · Brain Plasticity
  35. Neuroimmune Dysfunction in Alzheimer’s Disease and Other Forms of Dementia
    Takuya Yamane, Takeshi Yoshioka, Yusuke Shimo · 2024 · Chemical and Pharmaceutical Bulletin
  36. Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer’s disease pathology and in human post-mortem brain samples
    Marie‐Kim St‐Pierre, Micaël Carrier, Fernando Gonzàlez Ibáñez, Eva Šimončičová, Marie‐Josée Wallman, Luc Vallières, Martin Parent, Marie‐Ève Tremblay · 2022 · Research Square
  37. Serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury
    Gengfan Ye, Zhigang Wang, Pandi Chen, Junyi Ye, Shiwei Li, Maosong Chen, Jiugeng Feng, Hongcai Wang, Wei Chen · 2024 · Neuroscience
  38. Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters
    Kathryn J. Laloli, Peggy Rentsch, Sandy Stayte, Bryce Vissel · 2025 · Frontiers in Pharmacology
  39. Autosomal Dominant Alzheimer’s Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice
    Carmen Romero‐Molina, Sarah M. Neuner, Marcelina Ryszawiec, Alice Pébay, Dominantly Inherited Alzheimer Network, Edoardo M. Marcora, Alison Goate · 2024 · International Journal of Molecular Sciences
  40. Community Mediation Service: A Model for Teaching Democracy and Conflict Resolution.
    Christa Daryl Slaton · 1994
  41. Transplantation of wild-type hematopoietic stem and progenitor cells rescue Alzheimer’s disease in a mouse model and highlights the central role of microglia in disease pathogenesis
    Priyanka Mishra, Alexander Silva, Jay Sharma, Jacqueline Nguyen, Donald P. Pizzo, Debashis Sahoo, Stéphanie Cherqui · 2022 · Research Square
  42. Morphological and functional characteristics of LPS-stimulated microglial cells under the action of orexin A
    A. P. Synchikova, Elena A. Korneva · 2022 · Russian Journal of Immunology
  43. Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis
    Hiroki Miyahara, Jian Dai, Ying Li, Xiaoran Cui, Hibiki Takeuchi, Naomi Hachiya, Fuyuki Kametani, Masahide Yazaki, Masayuki Mori, Keiichi Higuchi · 2022 · Amyloid
  44. Neonatal microglia transplantation at early stage but not late stage after traumatic brain injury shows protective effects in mice
    Maosong Chen, Hongcai Wang, Pandi Chen, Guangyao Zhu, Shiwei Li, Zengpan Li, Xuelan Liu, Gengfan Ye, Wei Chen · 2024 · Journal of Neurophysiology
  45. The Impact of Ultrasound on APP/PS1 Model Mouse
    Li Li, Weiwei Wang, Wei Wu, Wanlin Zhang, Ying Gao, Chen Chen · 2017 · International Conference on Material Science, Energy and Environmental Engineering (MSEEE)
  46. Analysis of the causes and approaches to the regulation of the cytotoxic state of microglia in the aging brain
    Olga L Terekhina, Ю.И. Кирова · 2023 · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia»
  47. Novel drug therapies for cardiac amyloidosis
    Prakash Harikrishnan, Srikanth Yandrapalli, Wilbert S. Aronow, Gregg M. Lanier, Diwakar Jain · 2019 · Expert Opinion on Investigational Drugs
  48. Cellular Underpinnings of the Selective Vulnerability of Tauopathic Insults in Alzheimer's Disease
    Justin Torok, Pedro D. Maia, Chaitali Anand, Ashish Raj · 2024 · SSRN Electronic Journal
  49. Characterization of microglial Rab7 knockout on amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
    Beate Maren Erika Koch · 2019
  50. Macrophages in the reticuloendothelial system inhibit the propagation phase of mouse apolipoprotein A-II amyloidosis
    Hiroki Miyahara, Jian Dai, Ying Li, Cui Xiaoran, Hibiki Takeuchi, Naomi Hachiya, Fuyuki Kametani, Masahide Yazaki, Masayuki Mori, Keiichi Higuchi · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  51. References
    2018 · Elsevier eBooks
  52. Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer’s disease
    Justin Torok, Pedro D. Maia, Chaitali Anand, Ashish Raj · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Additional file 2 of Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina
    Qinyuan Xu, Pierre Boerkoel, Veronica Hirsch‐Reinshagen, Ian R. Mackenzie, Ging‐Yuek Robin Hsiung, Geoffrey Charm, Elliott To, Alice Liu, Katerina D. Schwab, Kailun Jiang et al. · 2022 · Figshare
  54. A Neuroinflammatory View of Alzheimer’s Disease
    Hymie Anisman, Shawn P. Hayley, Alexander Kusnecov · 2024 · Elsevier eBooks
  55. References
    2024 · Elsevier eBooks
  56. Pharmacotherapy of Alzheimer's disease: A thorny road to success
    Nurul Husna Ibrahim, Jaya Kumar, Wael M.Y. Mohamed · 2024 · Elsevier eBooks
  57. Formaldehyde, Neuroinflammation, and Cognitive Impairment
    Nianxin Kang, Ying Liu, Rongqiao He · 2025 · Springer eBooks
  58. Additional file 2 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  59. Additional file 9 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  60. Additional file 3 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  61. Additional file 1 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  62. Additional file 1 of Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges
    Wu, Chongyun, Luoman Yang, Feng, Shu, Zhu, Ling, Yang, Luodan, Timon Cheng‐Yi Liu, Rui Duan · 2022 · Figshare
  63. Additional file 6 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  64. Additional file 4 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  65. Additional file 8 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  66. Additional file 5 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  67. Additional file 7 of Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
    Shin, Hyo Jung, Kim, In Soo, Seung Gyu Choi, Lee, Kayoung, Park, Hyewon, Shin, Juhee, Dayoung Kim, Beom, Jaewon, Yi, Yoon Young, Deepak Prasad Gupta et al. · 2024 · Figshare
  68. Additional file 1 of Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina
    Qinyuan Alis Xu, Pierre Boerkoel, Veronica Hirsch‐Reinshagen, Ian R. Mackenzie, Hsiung, Ging-Yuek Robin, Geoffrey Charm, Elliott To, Liu, Alice Q., Katerina D. Schwab, Jiang, Kailun et al. · 2022 · Figshare
  69. Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software
    Lídia Sánchez-Puebla, Inés López‐Cuenca, Miguel A. Sánchez-Puebla, Ana Granados, AI RAMIREZ, Juan Lloréns, Takaomi C. Saido, Takashi Saito, Carmen Nieto‐Vaquero, María Ángeles Moro et al. · 2026 · Frontiers in Aging Neuroscience
  70. Influences biochimiques, anatomiques et cognitives de la troncation exopeptidasique N-terminale du peptide Aβ
    Audrey Valverde · 2020 · theses.fr (ABES)
  71. Altered neuronal activity in the hippocampal CA3 region in an in vitro model of tauopathy
    Ania Goncalves · 2020 · theses.fr (ABES)
  72. A protocol to establish and maintain organotypic cerebellar slice culture (OCerSC) from aged mice
    Michael F. Almeida, Kaitlan Smith, Michael A. Garris, Rebekah Sanchez‐Hodge, Meagan Colie, Jonathan Cummings Schisler · 2026 · PLoS ONE
  73. Organoid-based models in cerebrovascular disorders: Mechanistic insights and precision medicine
    Jiaxin Zhang, Yiren Zhang, Mengchen Yu, Chao‐Yu Miao, Haitao Sun · 2026 · Vascular Pharmacology
  74. Microglial Therapeutic Potential in Alzheimer’s Disease: From Phenotypic Diversity to Targeted Interventions
    Maria-Raluca Gogu, Ivona Costăchescu, Gabriela Dumitriţa Stanciu, Bogdan-Ionel Tamba, Mitică Ciorpac, Lucian Gorgan · 2026 · Pharmaceuticals
  75. Neuroinflammation in Alzheimer's disease: From glial cell states and molecular networks to biomarkers and precision therapeutics
    Priyanka Samantaray, Poonam Verma · 2026 · Molecular and Cellular Neuroscience
  76. BindingDB Entry 50022497: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
    BindingDB · 2025 · UC San Diego