The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy
Open accessAbstract
Mitophagy, the selective removal of damaged or excess mitochondria by autophagy, is an important process in cellular homeostasis. The outer mitochondrial membrane ( OMM ) proteins NIX , BNIP 3, FUNDC 1, and Bcl2‐L13 recruit ATG 8 proteins ( LC 3/ GABARAP ) to mitochondria during mitophagy. FKBP 8 (also known as FKBP 38), a unique member of the FK 506‐binding protein ( FKBP ) family, is similarly anchored in the OMM and acts as a multifunctional adaptor with anti‐apoptotic activity. In a yeast two‐hybrid screen, we identified FKBP 8 as an ATG 8‐interacting protein. Here, we map an N‐terminal LC 3‐interacting region ( LIR ) motif in FKBP 8 that binds strongly to LC 3A both in vitro and in vivo . FKBP 8 efficiently recruits lipidated LC 3A to damaged mitochondria in a LIR ‐dependent manner. The mitophagy receptors BNIP 3 and NIX in contrast are unable to mediate an efficient recruitment of LC 3A even after mitochondrial damage. Co‐expression of FKBP 8 with LC 3A profoundly induces Parkin‐independent mitophagy. Strikingly, even when acting as a mitophagy receptor, FKBP 8 avoids degradation by escaping from mitochondria. In summary, this study identifies novel roles for FKBP 8 and LC 3A, which act together to induce mitophagy.
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
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Metadata
- Authors
- Bhujabal, Z., Birgisdottir, Å. B., Sjøttem, E., Brenne, H. B., Øvervatn, A., Habisov, S., Kirkin, V., Lamark, T., & Johansen, T.
- Venue
- EMBO reports
- Published
- 2017-04-05
- Volume
- 18
- Issue
- 6
- Pages
- 947-961
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2604819250
- Cited by
- 417
- References
- 14
- FWCI
- 23.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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