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Lnc RNA ‐ PAGBC acts as a micro RNA sponge and promotes gallbladder tumorigenesis
Open accessAbstract
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis‐associated gallbladder cancer lncRNA (lncRNA‐PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA‐PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA‐PAGBC competitively binds to the tumour suppressive microRNAs miR‐133b and miR‐511. This competitive role of lncRNA‐PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA‐PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.
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Network biology: understanding the cell's functional organization
Barabási, A.-L., & Oltvai, Z. N. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1272 · Cited by 7,903
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262
Cited by
Liang, H., Yu, T., Han, Y., Jiang, H., Wang, C., You, T., Zhao, X., Shan, H., Yang, R., Yang, L., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0870-5 · Cited by 348
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Metadata
- Authors
- Wu, X., Wang, F., Li, H., Hu, Y., Jiang, L., Zhang, F., Li, M., Wang, X., Jin, Y., Zhang, Y., Lu, W., Wu, W., Shu, Y., Weng, H., Cao, Y., Bao, R., Liang, H., Wang, Z., Zhang, Y., Gong, W., Zheng, L., Sun, S., & Liu, Y.
- Venue
- EMBO reports
- Published
- 2017-09-08
- Volume
- 18
- Issue
- 10
- Pages
- 1837-1853
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2752304808
- Cited by
- 245
- References
- 2
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, X., Wang, F., Li, H., Hu, Y., Jiang, L., Zhang, F., Li, M., Wang, X., Jin, Y., Zhang, Y., Lu, W., Wu, W., Shu, Y., Weng, H., Cao, Y., Bao, R., Liang, H., Wang, Z., Zhang, Y., . . . Liu, Y. (2017). Lnc RNA ‐ PAGBC acts as a micro RNA sponge and promotes gallbladder tumorigenesis. EMBO reports. https://doi.org/10.15252/embr.201744147
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