Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

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  1. Additional file 6 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  2. Additional file 2 of Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders
    Jingxian Lun, Li, Yubin, Xuefeng Gao, Gong, Zelong, Chen, Xiaoliang, Jinhu Zou, Zhou, Chengxing, Huang, Yuanyuan, Bingliang Zhou, Pengwei Huang et al. · 2024 · Figshare
  3. Additional file 1 of Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
    Klébea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Liang, Heidi Y., Chu, Shu-Hui, Purnika Selvan, Ángela Gómez-Arboledas, Tiffany J. Petrisko, Fonseca, Maria I., Mortazavi, Ali et al. · 2022 · Figshare
  4. Additional file 1 of Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice
    Yeonggwang Hwang, HyoungChun Kim, Shin, Eun-Joo · 2022 · Figshare
  5. Additional file 2 of Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease
    Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Saido, Takaomi C., Saito, Takashi, Yamanaka, Koji · 2024 · Figshare
  6. Additional file 1 of HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats
    Li, Lilan, Li, Yu, He, Bingqiang, Li, Hui, Huiyuan Ji, Yingjie Wang, Zhu, Zhenjie, Hu, Yuming, Zhou, Yue, Yang, Ting et al. · 2021 · Figshare
  7. Additional file 9 of Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
    Yuriy Pomeshchik, Erika Velásquez, Jeovanis Gil, Oxana l. Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren‐Thorsson et al. · 2023 · Figshare
  8. Additional file 1 of Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
    Yuriy Pomeshchik, Erika Velásquez, Jeovanis Gil, Oxana l. Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren‐Thorsson et al. · 2023 · Figshare
  9. Additional file 1 of Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth
    James Nicholson, Cirigliano, S., Richa Singhania, Caroline Haywood, Shahidi Dadras, M., Yoshimura, M., Daniel B. Vanderbilt, Benjamin Liechty, Fine, H. A. · 2024 · Figshare
  10. Additional file 11 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  11. Additional file 3 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  12. Additional file 1 of Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders
    Jingxian Lun, Li, Yubin, Xuefeng Gao, Gong, Zelong, Chen, Xiaoliang, Jinhu Zou, Zhou, Chengxing, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang et al. · 2024 · Figshare
  13. Additional file 2 of HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats
    Li, Lilan, Li, Yu, He, Bingqiang, Li, Hui, Huiyuan Ji, Yingjie Wang, Zhu, Zhenjie, Hu, Yuming, Zhou, Yue, Yang, Ting et al. · 2021 · Figshare
  14. Additional file 1 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  15. Additional file 8 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  16. Additional file 7 of Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
    Yuriy Pomeshchik, Erika Velásquez, Jeovanis Gil, Oxana l. Klementieva, Ritha Gidlöf, Marie Sydoff, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gunilla Westergren‐Thorsson et al. · 2023 · Figshare
  17. Additional file 1 of Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status
    Rigina L. Gallagher, Rebecca L. Koscik, Jason F. Moody, Nicholas M. Vogt, Nagesh Adluru, Steven Kecskemeti, Van Hulle, Carol A., Nathaniel A. Chin, Asthana, Sanjay, Gwendlyn Kollmorgen et al. · 2024 · Figshare
  18. Additional file 4 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  19. Additional file 10 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  20. Additional file 7 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  21. Additional file 3 of Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease
    Ting Wang, Akira Sobue, Seiji Watanabe, Okiru Komine, Saido, Takaomi C., Saito, Takashi, Yamanaka, Koji · 2024 · Figshare
  22. Additional file 13 of Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
    Khalid Eltom, Tobias Mothes, Sylwia Libard, Ingelsson, Martin, Anna Erlandsson · 2024 · Figshare
  23. Riluzole shifts glial responses to protect synapses and memory in Aβ oligomer–treated rats
    Min-Kaung Wint-Mon, Hiroyuki Kida, Ryoichi Kimura, Dai Mitsushima · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Integrating CADD1 and UHPLC-ESI-HRMS2 to screen natural products for potential multi-target drugs against Alzheimer's disease
    Jinqi Yang, Yuan Cao, Shan Shu, Chunlin Yue, Zihan Shen, Yangyang Zhang, Zhenwen Zhao · 2026 · Results in Chemistry
  25. How Glial Cell Dysfunction Fuels Neurodegeneration in Alzheimer’s and Prion Diseases? Emerging Targets for Therapy
    Saima Zafar, Urwah Rasheed, Inga Zerr · 2026 · IntechOpen eBooks
  26. Astrocyte-Specific Upregulation of Tumor Necrosis Factor Receptor II Ameliorates Pathological Phenotypes in APPNL-F/NL-F Mice
    Dafeng Li, Yang Li, Lang Wen, Zuolong Chen, Feng Gao, Yong Shen, Qiong Wang · 2026 · Neuroscience Bulletin
  27. Hippocampal astrocyte St6galnac5 silencing improves spatial memory and preserves synaptic integrity in an AD mouse model
    Chunhong Xue, Chen Chen, Xiaoqiong Zou, Shiying Li, Yehua Lv, Wei Liu · 2026 · Experimental Neurology
  28. Amyloid precursor protein derivatives differentially alter the microRNA cargo of astrocyte-derived extracellular vesicles
    Aimee J. Chu, Anna Erlandsson, Joanna M. Williams · 2026 · Neuroscience
  29. Les astrocytes réactifs, des partenaires anti-agrégants dans la maladie de Huntington : identification des mécanismes impliqués dans le dialogue neurone-astrocyte
    Laurene Abjean · 2019 · theses.fr (ABES)
  30. Hétérogénéité de la réactivité astrocytaire dans la maladie d'Alzheimer
    Océane Guillemaud · 2020 · theses.fr (ABES)
  31. Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’Alzheimer
    Laurie Arnaud · 2021 · theses.fr (ABES)
  32. Implications de la signalisation de la protéine kinase activée par l’AMP (AMPK) dans les dysfonctions mitochondriales, la pathologie amyloïde et Tau, et la neuroinflammation dans la maladie d’Alzheimer
    Arnaud Mary · 2022 · theses.fr (ABES)
  33. Investigating the molecular signature of reactive astrocytes mediated by the JAK2- STAT3 pathway using different omics : transcriptomics and proteomics insights
    Miriam Riquelme‐Perez · 2023 · theses.fr (ABES)
  34. Hétérogénéité et régulation des astrocytes dans la maladie d'Alzheimer : vers des interventions ciblées sur les voies JAK2-STAT3 et NF-kB
    Yiannis Poulot-Becq-Giraudon · 2024 · theses.fr (ABES)
  35. Pathophysiology and Molecular Mechanisms of Alzheimer’s Disease
    Siva Sai Chandragiri, Manish Mathur, Neha Mathur · 2026 · BENTHAM SCIENCE PUBLISHERS eBooks
  36. Neuroinflammation and Secretase Regulation in Alzheimer’s Disease: From Molecular Cross-Talk to Multi-Target Therapeutics
    Giovanni Luca Cipriano, Ivan Anchesi, Ivana Raffaele, Maria Francesca Astorino, Aurelio Minuti, Marco Calabrò, Concetta Crisafulli · 2026 · International Journal of Molecular Sciences
  37. A post-inflammatory C3-high astrocyte state persists after inflammatory stimulus withdrawal and is attenuated by JAK inhibition
    Yogo Sakakibara, Kyohei Okahara, Jungo Kakuta, Kazumi Emoto, Yuri Ofusa, Kenji Ohba · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Inhibition of SUR1-TRPM4 attenuates astrocyte swelling and reactivity under oxygen-glucose deprivation/reoxygenation
    Yuanyuan Zhao, Narawut Pakaprot, Rujapope Sutiwisesak, Unchalee Vattarakorn, Sompol Tapechum · 2026 · PLoS ONE
  39. In vivo evidence for soluble Aβ oligomer-driven neuronal metabolic dysfunction in 5xFAD mice
    Chaynita Dashora, Anant Bahadur Patel · 2026 · Alzheimer s Research & Therapy
  40. STAT3 mediated the isoleucine-induced Alzheimer’s disease progression
    Yu Liu, Yuhe Li, Yanjun Zhou, Yu Hei, Shujing Wang, Akhilesh Kumar Bajpai, Xueying Chang, Xinhao Wang, Fuyi Xu, Cuifang Yao · 2026 · Brain Research
  41. A user-friendly single-nucleus RNA sequencing pipeline to identify alterations in gene expression in small brain circuits
    Gabriel S. Stephens, David Alcantara‐Gonzalez, Helen E. Scharfman · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Tofacitinib overrides first-line drug resistance in a pre-clinical model of epilepsy
    Jennifer L. Koehler, Olivia R. Hoffman, Quinn R. Harvey, Barry A. Schoenike, Jose Ezekiel Clemente Espina, Avtar Roopra · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Neuroinflammatory and molecular pathways in Alzheimer’s disease: mechanistic crosstalk and emerging therapeutic opportunities
    Abhay Thakur, Rohit R. Sharma, Sneha Kumari, Dev Prakash, A Sanjana Devi · 2026 · Inflammopharmacology
  44. Riluzole shifts glial responses to protect synapses and memory in Aβ oligomer–treated rats
    Min-Kaung-Wint-Mon, Hiroyuki Kida, Ryoichi Kimura, Dai Mitsushima · 2026 · Journal of Neuroinflammation
  45. Entorhinal cortex astrocytes in early Alzheimer disease: Human evidence, cross-species circuit rationale, and translational boundaries
    Fengjuan Wu, Manxia Wang · 2026 · Journal of Neuropathology & Experimental Neurology
  46. Post-translational modifications in Neuroimmune cells during neuroinflammation: integrated regulatory networks and therapeutic opportunities
    Wei Li, Yaqi Liu, Haoling Zhang, Haolong Zhang, Wenwen Shao, Ting Hu, Yan Liao, Wangzheqi Zhang, Xiaohong Kang · 2026 · Biology Direct
  47. Sequence-resolved discovery and cellular validation of immunomodulatory peptides from cricket protein hydrolysate
    Xinyue Qi, Yuhao Zhang, Yuliang Zhou, Vibhavari Aysha Bansal, Lijun Liu, Chewhui Pung, Leehow Lau, Hui Ye · 2026 · Future Foods
  48. Dynamic contributions of astrocytes in Alzheimer’s disease
    Fang Guo, Ting Li, Xi‐Biao He · 2026 · Experimental Neurology
  49. The Role of Astrocytes in the Inflammatory Response in Neurodiseases
    Shijun Peng, Lepeng Wang, Jia Ouyang, 刘如恩 · 2026 · MedComm
  50. BindingDB Entry 50023362: STATs, promising targets for the treatment of autoimmune and inflammatory diseases.
    BindingDB · 2026 · UC San Diego
  51. Inflammatory pathways in Alzheimer's disease: The immunometabolic perspective
    Shreyasi Majumdar, Puneet Kumar Samaiya, Yusuf Hussain, Santosh Kumar Prajapati · 2026 · Elsevier eBooks