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Cited by 73T-cell and B-cell ImmunologySystemic Lupus Erythematosus ResearchLymphoma Diagnosis and Treatment

Functions of double‐negative B cells in autoimmune diseases, infections, and cancers

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Chung, Michael King Yung, Gong, Lanqi, Kwong, Dora Lai‐Wan, Lee, Victor Ho‐Fun, Lee, Ann Wing‐Mui, Guan, Xin‐Yuan, Kam, Ngar‐Woon, Dai, Wei·2023·EMBO Molecular Medicine
DOI 10.15252/emmm.202217341PMC PMC10493577
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Abstract

Most mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27: IgD + CD27 − naïve B cells, IgD + CD27 + unswitched memory B cells, IgD − CD27 + switched memory B cells, and IgD − CD27 − double‐negative (DN) B cells. Despite their small population size in normal peripheral blood, DN B cells play integral roles in various diseases. For example, they generate autoimmunity in autoimmune conditions, while these cells may generate both autoimmune and antipathogenic responses in COVID‐19, or act in a purely antipathogenic capacity in malaria. Recently, DN B cells have been identified in nasopharyngeal carcinoma and non‐small‐cell lung cancers, where they may play an immunosuppressive role. The distinct functions that DN B cells play in different diseases suggest that they are a heterogeneous B‐cell population. Therefore, further study of the mechanisms underlying the involvement of DN B cells in these diseases is essential for understanding their pathogenesis and the development of therapeutic strategies. Further research is thus warranted to characterize the DN B‐cell population in detail.

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  • These DN B cells have been associated with several inflammatory chronic disorders, which suggests they might be involved in the inflammatory component of AD.

    “These DN B cells have been associated with several inflammatory chronic disorders which suggest that they might be involved in the inflammatory component of AD [91].”

    From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [91]

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Cited by

Sorted by citations

Authors
Chung, M. K. Y., Gong, L., Kwong, D. L., Lee, V. H., Lee, A. W., Guan, X., Kam, N., & Dai, W.
Affiliations
  • University of Hong Kong (HK)
  • University of Hong Kong - Shenzhen Hospital (CN)
Corresponding author
  • Kam, Ngar‐Woon
  • Dai, Wei
ORCID
Venue
EMBO Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2023-06-05
Volume
15
Issue
9
Pages
e17341-e17341
ISSN
  • 1757-4676 (ISSN-L)
  • 1757-4684
DOI
10.15252/emmm.202217341
PMC
PMC10493577
OpenAlex
W4379377003
Cited by
73
References
4
Citations by year
2026: 20 · 2025: 20 · 2024: 31 · 2023: 2
FWCI
2.03
Type
journal article
Language
en
Open access
Licence
Locations
  • EMBO Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
Funders
  • FHB | Health and Medical Research Fund (08192296)
  • Innovation and Technology Fund (Health@InnoHK)
  • Shenzhen Key Laboratory for Cancer Metastasis and Personalized Therapy (ZDSYS20210623091811035)
  • Theme‐based Research Scheme (T12‐703/22‐R)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords
double negative B cells, B cell subsets, IgD, CD27, naive B cells, memory B cells, autoimmunity, COVID-19 pandemic, malaria, nasopharyngeal carcinoma, non-small cell lung cancer, immunosuppression, B cell heterogeneity
MeSH terms
COVID-19, Autoimmune Diseases, B-Lymphocytes, Carcinoma, Non-Small-Cell Lung, Humans, Immunologic Memory, Lung Neoplasms

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