A Model for Intracellular Trafficking of Adenoviral Vectors
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Most existing viral vector models are vector specific and typically require re-derivation or extensive re-parameterization when applied to other viral systems.
“Most existing models are vector specific and typically require re-derivation or extensive re-parameterization when applied to other viral systems.”
From Mechanistic model for HEK293 viral vector processes and its application in a digital shadow framework (2026) · cites this paper as [15]
The Introduction and “Pharmacokinetic model versus current approach” section discuss limitations of earlier models, including simplified transport and fitted rate constants. The Conclusion says the authors’ approach could be applied to other viruses with appropriate modifications. None of these passages says that most existing models are vector specific or typically require re-derivation or extensive re-parameterization for other viral systems. (LLM, conf=0.72)
Experimental — accuracy not yet measuredFor adenovirus, existing models primarily focus on intracellular kinetics and diffusion driven infection and propagation dynamics.
“For adenovirus, existing models primarily focus on intracellular kinetics and diffusion driven infection and propagation dynamics [14, 15].”
From Mechanistic model for HEK293 viral vector processes and its application in a digital shadow framework (2026) · cites this paper as [15]
Several mechanistic modeling efforts have characterized HEK293 based viral vector production, although most of them remain vector specific.
“Several mechanistic modeling efforts have characterized HEK293 based viral vector production, although most of them remain vector specific.”
From Mechanistic model for HEK293 viral vector processes and its application in a digital shadow framework (2026) · cites this paper as [15]
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Research works printed but not linked: 3
- Lakadamyali, M., M. J. Rust, H. P. Babcock, and X. W. Zhuang. 2003. Visualizing infection of individual influenza viruses. Proc. Natl. Acad. Sci. USA. 100:9280-9285.
- Smith, G. A., S. Gross, and L. W. Enquist. 2001. Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons. Proc. Natl. Acad. Sci. USA. 98:3466-3470.
- Giannakakou, P., M. Nakano, K. C. Nicolaou, A. O'Brate, J. Yu, M. V. Blagosklonny, U. F. Greber, and T. Fojo. 2002. Enhanced microtubule- dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc. Natl. Acad. Sci. USA. 99:10855-10860.
Cited by
Sorted by citations
Kuchemüller, K. B., Austerjost, J., Machleid, R., Roßkamp, A., Niemann, J., & McCready, C. (2026) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-026-03362-2
- Authors
- Dinh, A.-T., Theofanous, T., & Mitragotri, S.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 89
- Issue
- 3
- Pages
- 1574-1588
- ISSN
- 0006-3495
- Cited by
- 65
- References
- 0
- Language
- en
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