Confinement and manipulation of actin filaments by electric fields
Open accessAbstract
When an AC electric field was applied across a small gap between two metal electrodes elevated above a surface, rhodamine-phalloidin-labeled actin filaments were attracted to the gap and became suspended between the two electrodes. The variance <s2(x)> of each filament's horizontal, lateral displacement was measured as a function of electric field intensity and position along the filament. <s2(x)> markedly decreased as the electric field intensity increased. Hypothesizing that the electric field induces tension in the filament, we estimated the tension using a linear, Brownian dynamic model. Our experimental method provides a novel means for trapping and manipulating biological filaments and for probing the surface conductance and mechanical properties of single polymers.
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Like MTs, AFs can be manipulated by external electric fields.
“Like MTs [96], AFs can be manipulated by external electric fields [113].”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [113]
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References 13 · Cited by 41
- Authors
- Arsenault, M. E., Zhao, H., Purohit, P. K., Goldman, Y. E., & Bau, H. H.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Goldman, Yale E.
- Bau, Haim H.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 93
- Issue
- 8
- Pages
- L42-L44
- ISSN
- 0006-3495 (ISSN-L)
- PMC
- PMC1989696
- OpenAlex
- W2156947670
- Cited by
- 41
- References
- 13
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biophysical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ScholarlyCommons (University of Pennsylvania) (submittedVersion)
- Scholarly Commons (University of Pennsylvania) (submittedVersion)
- Funders
- National Science Foundation (DMR-0425780)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Keywords
- F-actin, AC electric field, Brownian dynamics, surface conductance, polymer mechanical properties
- MeSH terms
- Computer Simulation, Dose-Response Relationship, Radiation, Elasticity, Electrochemistry, Electromagnetic Fields, Actin Cytoskeleton, Micromanipulation, Models, Chemical, Models, Molecular, Protein Conformation, Radiation Dosage, Stress, Mechanical
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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