EFFECT OF ANTITHYROID TREATMENT ON CALCIUM-PHOSPHORUS METABOLISM IN HYPERTHYROIDISM
Abstract
Histomorphometric analysis of iliac crest biopsies was performed after tetracycline double-labelling in 22 hyperthyroid patients before and after medical antithyroid treatment for an average period of 4 months. The initially increased cortical porosity was normalized during treatment whereas the amount of trabecular bone was unchanged. The osteoclastic resorption in cortical bone decreased but was still elevated. The osteocytic osteolysis remained slightly increased. In trabecular bone, however, the bone turn-over decreased to a subnormal level following treatment and the surfaces were inactive in bone resorption and bone formation. An increase was observed in the amount, extent and width of osteoid seams due to an increase in the lifespan of bone forming sites and a prolongation of the maturity period of osteoid. The observed increased deposition of cortical bone after antithyroid treatment may explain the positive calcium balance in this period.
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Hyperthyroidism causes high bone turnover with increased frequency of initiation of bone remodelling sites together with increased bone resorption and formation rates.
“Hyperthyroidism, in contrast, causes high bone turnover with an increased frequency of initiation of bone remodelling sites together with increased bone resorption and formation rates.”
From Thyroid diseases and bone health (2018) · cites this paper as [24]
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Cited by 61
- Authors
- Mosekilde, L., & Melsen, F.
- Affiliations
- Aarhus University (DK)
- ORCID
- Mosekilde, Leif
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1978-04
- Volume
- 87
- Issue
- 4
- Pages
- 751-758
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2088907250
- Cited by
- 61
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2012: 2
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- antithyroid drug therapy, hyperthyroidism, calcium and phosphorus metabolism, bone turnover, cortical porosity, trabecular bone, osteoclast resorption, osteoid seams, bone formation, calcium balance
- MeSH terms
- Adult, Aged, Bone and Bones, Bone Resorption, Calcium, Carbimazole, Female, Humans, Hyperthyroidism, Male, Middle Aged, Osteoclasts, Phosphorus, Thyroid Hormones, Thyroxine
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