The relation between gastrin, gastric acid and thyroid function disorders
Abstract
Hypergastrinaemia was found in 11 out of 24 untreated hyperthyroid patients (Graves' disease or nodular goitre). Seven patients had a co-existent (autoimmune) atrophic gastritis. In the remaining 17 patients plasma T3 was positively related to plasma gastrin, and negatively to gastric acid output; there was no relation between gastrin levels and acid output. Acid instillation into the stomach revealed a normal negative feedback of acid upon gastrin release. Sixteen hyperthyroid patients were restudied when euthyroid. Plasma gastrin decreased from 171 (51-1188) ng/l before treatment to 69 (39-392 ng/l after treatment (P < 0.002), and maximal acid output increased from 1.55 (0.00-22.75) to 8.03 (0.00-26.60) mmol H+/h (P < 0.01) (median values; range in brackets). However, in 4 patients with complete achlorhydria before and after treatment plasma gastrin decreased to the same extent as in the patients with gastric acid secretion. We conclude that thyrotoxic hypergastrinaemia cannot be fully explained by the low gastric acid output in hyperthyroidism.
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Gastrin exerts a thyroid function-dependent influence on GI motility.
“Gastrin exerts a thyroid function-dependent influence on GI motility (Wiersinga and Touber, 1980).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Wiersinga and Touber, 1980
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Thyroid disorders and gastrointestinal dysmotility: an old association
Xu, G.-M., Hu, M.-X., Li, S.-Y., Ran, X., Zhang, H., & Ding, X.-F. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1389113 · Cited by 43 · see citing works
- Authors
- Wiersinga, W. M., & Touber, J. L.
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-11
- Volume
- 95
- Issue
- 3
- Pages
- 341-349
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W1972751463
- Cited by
- 18
- References
- 0
- Citations by year
- 2024: 3 · 2023: 1 · 2021: 3
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- gastrin, gastric acid secretion, hyperthyroidism, Graves' disease, nodular goiter, hypergastrinemia, thyroid function abnormalities, atrophic gastritis, achlorhydria, antithyroid drug therapy
- MeSH terms
- Adult, Aged, Female, Gastric Acid, Gastrins, Gastritis, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Thyroid Hormones
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