Frequency of hypoglycemia in children with adrenal insufficiency
Abstract
The frequency of hypoglycemia in 165 children with primary adrenal insufficiency, 118 of whom had Congenital Adrenal Hyperplasia and 47 Addison's Disease, was 18%. Half of the hypoglycemic episodes occurred in the neonatal period. Hypoglycemia was isolated in 13 children, revealing the disease in 4 newborns with Congenital Adrenal Hypoplasia and in a boy with 11 B Hydroxylase deficiency. Basal plasma cortisol levels were significantly lower in those of subjects who experienced hypoglycemia (47.1 +/- 28.6 ng/ml vs. 106.0 +/- 86.6 ng/ml, p less than 0.001). A significant correlation (p less than 0.001) was found between the plasma concentration of glucose and cortisol at time of hypoglycemia.
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Children and infants with primary adrenal insufficiency who experienced hypoglycaemia had a significantly lower basal cortisol level.
“Those who experienced hypoglycaemia had a significantly lower basal cortisol level.”
From Hypoglycaemia in adrenal insufficiency (2023) · cites this paper as [38]
In a study conducted in France, 30 out of 165 (18%) children and infants with primary adrenal insufficiency experienced hypoglycaemic episodes.
“In children, a study conducted in France reported 30 out of 165 (18%) children and infants with PAI experienced hypoglycaemic episodes.”
From Hypoglycaemia in adrenal insufficiency (2023) · cites this paper as [38]
All hypoglycaemic episodes in that French study were associated with prior fasting or poor oral intake due to vomiting or viral illness.
“Additionally, all of these hypoglycaemic episodes were associated with prior fasting or poor oral intake due to vomiting or viral illness (38).”
From Hypoglycaemia in adrenal insufficiency (2023) · cites this paper as [38]
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Weise, M., Drinkard, B., Mehlinger, S. L., Holzer, S. M., Eisenhofer, G., Charmandari, E., Chrousos, G. P., & Merke, D. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032051 · Cited by 75 · see citing works
Weise, M., Mehlinger, S. L., Drinkard, B., Rawson, E., Charmandari, E., Hiroi, M., Eisenhofer, G., Yanovski, J. A., Chrousos, G. P., & Merke, D. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030634 · Cited by 67 · see citing works
Guettier, J.-M., & Gorden, P. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.09.005 · Cited by 68 · see citing works
Hypoglycaemia in adrenal insufficiency
Lee, S. C., Baranowski, E. S., Sakremath, R., Saraff, V., & Mohamed, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1198519 · Cited by 32 · see citing works
“Additionally, all of these hypoglycaemic episodes were associated with prior fasting or poor oral intake due to vomiting or viral illness (38).”
BackgroundStress doses of glucocorticoids cannot prevent progression of all adrenal crises
Aso, K., Izawa, M., Higuchi, A., Kotoh, S., & Hasegawa, Y. (2009) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.18.23 · Cited by 17 · see citing works
Diagnosis and treatment of ACTH deficiency
Cooper, M. S., & Stewart, P. M. (2005) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-005-5224-0 · Cited by 16 · see citing works
- Authors
- Artavia-Loria, E., Chaussain, J. L., Bougnères, P. F., & Job, J. C.
- Affiliations
- Hôpital Saint-Vincent-de-Paul (FR)
- Venue
- Acta Endocrinologica
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-12
- Volume
- 113
- Issue
- 4_Suppl
- Pages
- S275-S278
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2107961995
- Cited by
- 40
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 3 · 2020: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- hypoglycemia, Addison's disease, congenital adrenal hyperplasia, congenital adrenal hypoplasia, 11beta-hydroxylase deficiency, plasma cortisol, neonatal hypoglycemia, children
- MeSH terms
- Addison Disease, Adolescent, Adrenal Insufficiency, Adrenal Hyperplasia, Congenital, Child, Child, Preschool, Humans, Hydrocortisone, Hypoglycemia, Infant, Infant, Newborn
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