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Cited by 86Birth, Development, and HealthPregnancy and preeclampsia studiesHormonal Regulation and Hypertension

Differences in expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender

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Mericq, V, Medina, P, Kakarieka, E, Márquez, L, Johnson, M C, Iñiguez, G·2009·European Journal of Endocrinology
DOI 10.1530/eje-09-0308
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Abstract

BACKGROUND: Fetal exposure to maternal glucocorticoids may determine fetal growth and the programing of later disorders. Availability of the glucocorticoids in the placenta is regulated by the 11beta-hydroxysteroid dehydrogenase (11beta-HSDs) enzymes. To date, there are discrepancies with regard to cortisol (F) cord blood levels in fetuses with intrauterine growth retardation in different species. Objective To study the expression and activity of 11beta-HSDs in placentas from full term small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA) newborns, and cortisol cord blood concentration. METHODS: Twenty-five placentas from AGA, 24 SGA and 25 LGA were collected. RESULTS: SGA newborns had significantly lower and LGA newborns had significantly higher birth weight, birth length, head circumference, and placental weight than AGA counterparts. We observed a direct correlation between placental weight and birth weight, birth length and head circumference, and higher cord F levels in SGA newborns. The 11beta-HSD1 expression was similar among the SGA, AGA, and LGA placentas. However, within the placentas of SGA newborns, the 11beta-HSD1 mRNA levels were significantly reduced in the chorionic plate compared with basal plate. An inverse correlation between cord F levels and activity of 11beta-HSD1 in the chorionic plate of the SGA placentas was detected. The 11beta-HSD2 activity was seven- to eightfold higher compared with 11beta-HSD1 in the placentas, and there was a lower 11beta-HSD2 activity in females' SGA placentas compared with the male SGA placentas. CONCLUSION: We observed a lower expression and activity of 11beta-HSD1 in the chorionic plate of the SGA placentas, suggesting a possible compensatory mechanism to diminish the higher cortisol fetal concentrations observed in fetuses with intrauterine growth restriction.

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  • The female placenta may facilitate higher glucocorticoid exposure, as the activity of 11β-HSD1 and 11β-HSD2 responsible for cortisol metabolism was altered in the placenta of females.

    “The female placenta may facilitate higher glucocorticoid exposure, as the activity of the 11β-hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 11β-HSD2) responsible for cortisol metabolism was found to be altered in the placenta of females [117,119].”

    From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [119]

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Authors
Mericq, V, Medina, P., Kakarieka, E., Márquez, L., Johnson, M. C., & Iñiguez, G.
Affiliations
  • University of Chile (CL)
  • Hospital San Borja Arriarán (CL)
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2009-09
Volume
161
Issue
3
Pages
419-425
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-09-0308
OpenAlex
W2166379037
Cited by
86
References
0
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 10 · 2021: 3 · 2020: 4 · 2019: 15 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 5 · 2013: 6 · 2012: 9
FWCI
4.43
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
11β-hydroxysteroid dehydrogenase type 1, 11β-hydroxysteroid dehydrogenase type 2, placenta, small for gestational age, fetal growth restriction, fetal cortisol, chorionic plate, birth weight, fetal programming, maternal glucocorticoids, fetal growth
MeSH terms
Birth Weight, Chorion, Female, Fetal Growth Retardation, Gestational Age, Humans, Infant, Newborn, Infant, Small for Gestational Age, Male, Placenta, Pregnancy, Pregnancy Trimester, Third, Sex Factors, Gene Expression Regulation, Enzymologic, 11-beta-Hydroxysteroid Dehydrogenase Type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Term Birth

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