CoChat
Sign Up
Cited by 128Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsSperm and Testicular Function

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study

Yeap, Bu B, Chubb, S A Paul, Hyde, Zoë, Jamrozik, Konrad, Hankey, Graeme J, Flicker, Leon, Norman, Paul E·2009·European Journal of Endocrinology
DOI 10.1530/eje-09-0348
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Insulin resistance is associated with metabolic syndrome and type 2 diabetes, representing a risk factor for cardiovascular disease. This relationship may be modulated to some extent by age-related changes in sex hormone status. We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity. DESIGN: Cross-sectional analysis of 2470 community-dwelling non-diabetic men aged > or = 70 years. METHODS: Age, body mass index (BMI) and waist circumference were measured. Early morning sera were assayed for total testosterone, SHBG, LH and insulin levels. Free testosterone was calculated using mass action equations, and insulin resistance was assessed using a homeostatic model (HOMA2-IR). RESULTS: Total testosterone, free testosterone and SHBG declined progressively across increasing quintiles of HOMA2-IR (all P<0.001) and correlated inversely with log HOMA2-IR (r=-0.27, -0.14 and -0.24 respectively, all P<0.001). After adjusting for age, BMI, waist circumference, high-density lipoprotein and triglyceride levels, total testosterone was independently associated with log HOMA2-IR (beta=0.05, P<0.001), while SHBG was not. Serum total testosterone <8 nmol/l was associated with HOMA2-IR in the highest quintile (odds ratio (OR) 1.67, 95% confidence interval (CI) 1.02-2.73) as was total testosterone > or = 8 and <15 nmol/l (OR 1.29, 95% CI 1.03-1.63). CONCLUSIONS: In older men, lower total testosterone is associated with insulin resistance independently of measures of central obesity. This association is seen with testosterone levels in the low to normal range. Further studies are needed to evaluate interventions that raise testosterone levels in men with reduced insulin sensitivity.

Overview

Integrity signals

Registry

Crossref · 10.1530/eje-09-0348

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 41 references

Cited by

Sorted by citations

Items 101–128 of 128

Related

See all

Metadata

Authors
Yeap, B. B., Chubb, S. A. P., Hyde, Z., Jamrozik, K., Hankey, G. J., Flicker, L., & Norman, P. E.
Affiliations
  • The University of Western Australia (AU)
  • The University of Adelaide (AU)
Corresponding author
Yeap, Bu B
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2009-10
Volume
161
Issue
4
Pages
591-598
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-09-0348
OpenAlex
W2151358666
Cited by
128
References
41
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 13 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 11
FWCI
9.21
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
insulin resistance, total testosterone, sex hormone-binding globulin, older men, HOMA2-IR, abdominal obesity, sex hormones, metabolic syndrome, testosterone replacement therapy, Health in Men Study
MeSH terms
Aged, Anthropometry, Cross-Sectional Studies, Health, Humans, Insulin, Insulin Resistance, Luteinizing Hormone, Lipoproteins, Male, Obesity, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone, Western Australia, Body Mass Index, Multivariate Analysis, Adiposity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review