The diagnosis of Cushing’s syndrome: an Endocrine Society Clinical Practice Guideline: commentary from a European perspective
Abstract
Cushing's syndrome is considered a rare disease and its diagnosis can be challenging. Establishment of evidence-based recommendations is difficult. In 2008, several national and international consensus recommendations for the diagnosis or management of Cushing's syndrome were reported. The Endocrine Society, with the participation of the European Society of Endocrinology, has developed a task force to update recommendations for the diagnosis of Cushing's syndrome. The main aspects of these recommendations are presented in this article and discussed in the context of current research efforts in Europe focusing on the improvement of diagnosis and management of rare diseases including adrenal disorders such as Cushing's syndrome.
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A recent guideline update suggests LNSC has 97% sensitivity and 97.5% specificity in diagnosing Cushing's syndrome and 75-90% sensitivity and 93-95% specificity in diagnosing recurrent Cushing's disease.
“A recent guideline update on CS diagnosis and management suggests LNSC has 97% sensitivity and 97.5% specificity in diagnosing CS and 75–90% sensitivity and 93–95% specificity in diagnosing recurrent CD.”
From Late-night salivary cortisol and cortisone should be the initial screening test for cushing's syndrome (2022) · cites this paper as [3]
A guideline update recommends only using LNSC if cortisone concentrations can also be reported if an adrenal tumour is suspected.
“The previously mentioned guideline update on CS diagnosis and management recommends only using LNSC if cortisone concentrations can also be reported if an adrenal tumour is suspected (3).”
From Late-night salivary cortisol and cortisone should be the initial screening test for cushing's syndrome (2022) · cites this paper as [3]
UFC has 91% sensitivity and 81.5% specificity in diagnosing Cushing's syndrome and 68% sensitivity and 100% specificity in diagnosing recurrent Cushing's disease.
“Moreover, UFC has 91% sensitivity and 81.5% specificity in diagnosing CS and 68% sensitivity and 100% specificity in diagnosing recurrent CD (3).”
From Late-night salivary cortisol and cortisone should be the initial screening test for cushing's syndrome (2022) · cites this paper as [3]
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References 20 · Cited by 101
- Authors
- Guignat, L., & Bertherat, J.
- Affiliations
- Hôpital Cochin (FR)
- ORCID
- Guignat, Laurence
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07
- Volume
- 163
- Issue
- 1
- Pages
- 9-13
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2130957090
- Cited by
- 101
- References
- 20
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 3 · 2016: 12 · 2015: 8 · 2014: 10 · 2013: 3 · 2012: 7
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- Cushing's syndrome, diagnosis, Endocrine Society, rare diseases, adrenal disorders, hypercortisolism, diagnostic recommendations
- MeSH terms
- Cushing Syndrome, Europe, Humans, Societies, Medical, Guidelines as Topic
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