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Cited by 107Thyroid Disorders and TreatmentsOphthalmology and Eye DisordersAdrenal Hormones and Disorders

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Predictive value of maternal second-generation thyroid-binding inhibitory immunoglobulin assay for neonatal autoimmune hyperthyroidism

Abeillon-du Payrat, Juliette, Chikh, Karim, Bossard, Nadine, Bretones, Patricia, Gaucherand, Pascal, Claris, Olivier, Charrié, Anne, Raverot, Véronique, Orgiazzi, Jacques, Borson-Chazot, Françoise, Bournaud, Claire·2014·European Journal of Endocrinology
DOI 10.1530/eje-14-0254
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Abstract

Context: Hyperthyroidism occurs in 1% of neonates born to mothers with active or past Graves' disease (GD). Current guidelines for the management of GD during pregnancy were based on studies conducted with first-generation thyroid-binding inhibitory immunoglobulin (TBII) assays. Objective: This retrospective study was conducted in order to specify the second-generation TBII threshold predictive of fetal and neonatal hyperthyroidism, and to identify other factors that may be helpful in predicting neonatal hyperthyroidism. Methods: We included 47 neonates born in the Lyon area to 42 mothers harboring measurable levels of TBII during pregnancy. TBII measurements were carried out in all mothers; bioassays were carried out in 20 cases. Results: Nine neonates were born with hyperthyroidism, including five with severe hyperthyroidism requiring treatment. Three neonates were born with hypothyroidism. All hyperthyroid neonates were born to mothers with TBII levels >5 IU/l in the second trimester (sensitivity, 100% and specificity, 43%). No mother with TSH receptor-stimulating antibodies (TSAb measured by bioassay) below 400% gave birth to a hyperthyroid neonate. Among mothers of hyperthyroid neonates, who required antithyroid drugs during pregnancy, none could stop treatment before delivery. Analysis of TBII evolution showed six unexpected cases of increasing TBII values during pregnancy. Conclusion: Maternal TBII value over 5 IU/l indicates a risk of neonatal hyperthyroidism. Among these mothers, a TSAb measurement contributes to identify more specifically those who require a close fetal thyroid ultrasound follow-up. These results should be confirmed in a larger series.

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Crossref · 10.1530/eje-14-0254

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Research works printed but not linked: 4

  1. Costagliola, 1999, Journal of Clinical Endocrinology & Metabolism, 84, 90, 10.1210/jc.84.1.90 · DOI
  2. 1992, Obstetrics & Gynecology, 80, 359
  3. 1989, Thyroidology / A.P.R.I.M, 1, 73
  4. Kung, 1998, Journal of Clinical Endocrinology & Metabolism, 83, 514, 10.1210/jc.83.2.514 · DOI

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Metadata

Authors
Abeillon-du Payrat, J., Chikh, K., Bossard, N., Bretones, P., Gaucherand, P., Claris, O., Charrié, A., Raverot, V., Orgiazzi, J., Borson-Chazot, F., & Bournaud, C.
Affiliations
  • Inserm (FR)
  • Lyon 1 Université (FR)
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2014-10
Volume
171
Issue
4
Pages
451-460
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-14-0254
OpenAlex
W2137096201
Cited by
107
References
45
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 8 · 2018: 17 · 2017: 10 · 2016: 10 · 2015: 3
FWCI
6.15
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
neonatal hyperthyroidism, neonatal hypothyroidism
MeSH terms
Adult, Female, France, Graves Disease, Humans, Infant, Newborn, Infant, Newborn, Diseases, Male, Predictive Value of Tests, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Retrospective Studies, Thyroid Gland, Biomarkers, Immunoglobulins, Thyroid-Stimulating

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