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Cited by 287

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey 2016

Open access
McCormack, Ann, Dekkers, Olaf M, Petersenn, Stephan, Popovic, Vera, Trouillas, Jacqueline, Raverot, Gerald, Burman, Pia, _, _, _, _, Hubalewska-Dydejezky, Alicia, Assie, Guillaume, Bach, Leon, Batisse-Lignier, Marie, Berinder, Katarina, Bilbao, Ismene, Bonnet, Fabrice, Bresson, Damien, Bruno, Oscar, Campdera, Mariana, Caron, Philippe, Castinetti, Frederic, Ceccato, Filippo, Chabre, Olivier, Chanson, Philippe, Christ, Emanuel, Cloix, Lucie, Cortet, Christine, Criniere, Lise, Cuatrecasas, Guillem, Debono, Miguel, Delemer, Brigitte, Desailloud, Rachel, Deutschbein, Timo, Dusek, Tina, Engström, Britt Eden, Faustini-Fustini, Marco, Franck, Schillo, Garcia, Cyril, Greenman, Yona, Gil, Susana Mallea, Mantovani, Giovanna, Gurnell, Mark, Heaney, Anthony, Henley, David, Higham, Claire, Hoving, EW, Höybye, Charlotte, Ichihara, Atsuhiro, Jaffrain-Rea, Marie-Lise, Johannsson, Gudmundur, Jorgensen, Jens Otto Lunde, Jublanc, Christel, Komor, Jan, Korbonits, Marta, Kralievic, Ivana, Larrieu-Ciron, Delphine, Lasolle, Helene, Laws, Edward, Losa, Marco, Maiter, Dominique, Marcocci, Claudio, Marques, Olinda Castro, Mazzuco, Tania Longo, Micko, Alexander, Bourcigaux, Nathalie, Neggers, Sebastian, Newell-Price, John, Perez-Berida, Belén, Ortiz, Leon D, Ragnarsson, Oskar, Ragonese, Marta, Reincke, Martin, Sadoul, Jean-Louis, Shimatsu, Akira, Syro, Luis V, Taillandier, Luc, Toth, Miklos, Usui, Takeshi, Valkusz, Zauzsanna, Vila, Greisa, Whitelaw, Ben, Zatelli, Maria Chiara·2018·European Journal of Endocrinology
DOI 10.1530/eje-17-0933
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Abstract

Objective: To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects of temozolomide (TMZ) treatment. Design: Electronic survey to ESE members Dec 2015–Nov 2016. Results: Reports on 166 patients (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4–79) years. 69% of the tumours were clinically functioning, and the most frequent immunohistochemical subtype were corticotroph tumours (45%). Ki-67 index did not distinguish APT from PC, median 7% and 10% respectively. TMZ was first-line chemotherapy in 157 patients. At the end of the treatment (median 9 cycles), radiological evaluation showed complete response (CR) in 6%, partial response (PR) in 31%, stable disease (SD) in 33% and progressive disease in 30%. Response was more frequent in patients receiving concomitant radiotherapy and TMZ. CR was seen only in patients with low MGMT expression. Clinically functioning tumours were more likely to respond than non-functioning tumours, independent of MGMT status. Of patients with CR, PR and SD, 25, 40 and 48% respectively progressed after a median of 12-month follow-up. Other oncological drugs given as primary treatment and to TMZ failures resulted in PR in 20%. Conclusion: This survey confirms that TMZ is established as first-line chemotherapeutic treatment of APT/PC. Clinically functioning tumours, low MGMT and concurrent radiotherapy were associated with a better response. The limited long-term effect of TMZ and the poor efficacy of other drugs highlight the need to identify additional effective therapies.

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Authors
McCormack, A., Dekkers, O. M., Petersenn, S., Popovic, V., Trouillas, J., Raverot, G., Burman, P., _, _., _, _., Hubalewska-Dydejezky, A., Assie, G., Bach, L., Batisse-Lignier, M., Berinder, K., Bilbao, I., Bonnet, F., Bresson, D., Bruno, O., Campdera, M., Caron, P., Castinetti, F., Ceccato, F., Chabre, O., Chanson, P., Christ, E., Cloix, L., Cortet, C., Criniere, L., Cuatrecasas, G., Debono, M., Delemer, B., Desailloud, R., Deutschbein, T., Dusek, T., Engström, B. E., Faustini-Fustini, M., Franck, S., Garcia, C., Greenman, Y., Gil, S. M., Mantovani, G., Gurnell, M., Heaney, A., Henley, D., Higham, C., Hoving, E., Höybye, C., Ichihara, A., Jaffrain-Rea, M.-L., Johannsson, G., Jorgensen, J. O. L., Jublanc, C., Komor, J., Korbonits, M., Kralievic, I., Larrieu-Ciron, D., Lasolle, H., Laws, E., Losa, M., Maiter, D., Marcocci, C., Marques, O. C., Mazzuco, T. L., Micko, A., Bourcigaux, N., Neggers, S., Newell-Price, J., Perez-Berida, B., Ortiz, L. D., Ragnarsson, O., Ragonese, M., Reincke, M., Sadoul, J.-L., Shimatsu, A., Syro, L. V., Taillandier, L., Toth, M., Usui, T., Valkusz, Z., Vila, G., Whitelaw, B., & Zatelli, M. C.
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2018-03
Volume
178
Issue
3
Pages
265-276
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-17-0933
OpenAlex
W2784054425
Cited by
287
References
1
FWCI
21.49
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey 2016. https://app.cochat.ai/papers/10.1530/eje-17-0933
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McCormack, A., Dekkers, O. M., Petersenn, S., Popovic, V., Trouillas, J., Raverot, G., Burman, P., _, _., _, _., Hubalewska-Dydejezky, A., Assie, G., Bach, L., Batisse-Lignier, M., Berinder, K., Bilbao, I., Bonnet, F., Bresson, D., Bruno, O., Campdera, M., . . . Zatelli, M. C. (2018). Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey 2016. European Journal of Endocrinology. https://doi.org/10.1530/eje-17-0933

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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