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Proinsulin, C-peptide, and insulin in normal subjects during an 8-h hyperglycemic clamp
Abstract
Hartling SG, Røder ME, Dinesen B, Binder C. Proinsulin C-peptide, and insulin in normal subjects during an 8-h hyperglycemic clamp. Eur J Endocrinol 1996;134:197–200. ISSN 0804–4643 Increased concentrations of proinsulin immunoreactive material (PIM) absolutely or relative to insulin is a characteristic finding in patients with non-insulin-dependent diabetes mellitus (NIDDM). The aim of this study was to test if 8 h or mild hyperglycemia (7–9 nmol/l in healthy subjects could induce a preferential secretion of PIM from B cells. Serum concentrations of insulin, C-peptide and PIM were measured every 10 min during the 8 h of continuous glucose infusion in nine normal-weight healthy subjects without diabetes among their first-degree relatives. After a gradual rise in B-cell peptides, a steady state was reached. From 4 to 8 h no further difference in insulin, C-peptide or PIM concentration was found. Fasting PIM/C-peptide and PIM/insulin ratios of 0.5% and 2.3% increased during the glucose clamp to levels of 1.4% and 7.6%, respectively. Neither testing the regression slope nor comparing individual time points showed any significant difference for the PIM/C-peptide ratio from 2 to 8 h and for the PIM/insulin ratio from 3 to 8 h. These results do not support the hypothesis that an increased glucose drive per se results in an altered B-cell function with increasing PIM/Cpeptide ratio. At least 8 h of mild hyperglycemia in healthy subjects does not progressively alter B-cell function. Svend Hartling, Department of Internal Medicine, Sundby Hospital, Italiensvej 1, DK-2300 Sundby, Denmark
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“This thesis is based on the observation that in apparently healthy subjects the production of hyperglycaemia by a continuous infusion of glucose for periods of up to 42-h is associated with enhancements of insulin sensitivity [141] and beta-cell function [141, 142, 143, 144], rather than the production of insulin resistance and beta-cell dysfunction.”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [144]
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HARTLING, S. G., Knip, M., Roder, M., Dinesen, B., Hk, Å., & Binder, C. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370490 · Cited by 11
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Metadata
- Authors
- Hartling, S. G., Røder, M. E., Dinesen, B., & Binder, C.
- Corresponding author
- Hartling, Svend G
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-02
- Volume
- 134
- Issue
- 2
- Pages
- 197-200
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W1975893616
- Cited by
- 16
- References
- 0
- Citations by year
- 2021: 1 · 2017: 1
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- proinsulin, C-peptide, insulin, hyperglycemic clamp, beta-cell function, type 2 diabetes, healthy volunteers, glucose infusion
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, C-Peptide, Female, Glucose, Humans, Hyperglycemia, Insulin, Male, Middle Aged, Proinsulin, Glucose Clamp Technique
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