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Cited by 132Thyroid Disorders and TreatmentsOphthalmology and Eye DisordersThyroid and Parathyroid Surgery

The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.

Predictors of outcome and comparison of different drug regimens for the prevention of relapse in patients with Graves' disease

Nedrebo, BG, Holm, PI, Uhlving, S, Sorheim, JI, Skeie, S, Eide, GE, Husebye, ES, Lien, EA, Aanderud, S·2002·European Journal of Endocrinology
DOI 10.1530/eje.0.1470583
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Abstract

OBJECTIVE: To investigate the effect of different antithyroid drug (ATD) regimens on relapse rates of Graves' disease, and to look for predictors of relapse. DESIGN AND METHODS: In a prospective two-way factorial randomized clinical trial, 218 patients with Graves' disease were assigned to ATD combined with l-thyroxine (l-T(4)) or ATD alone for 12 Months. After discontinuation of antithyroid therapy, each group was stratified to either 12 Months further treatment with l-T(4) or no treatment. Clinical and biochemical assessments were carried out before treatment, after 3 and 6 weeks, and every third Month for 12 Months. If the patients lacked symptoms of relapse, laboratory tests were performed every third Month for the second Year, and thereafter annually. RESULTS: The proportion of all patients with relapse was 47.7% 2 Years after withdrawal of ATD. There was no difference in relapse rates between the treatment groups (P=0.217, log--rank test). Smokers had a higher relapse rate than non-smokers (58.4% vs 38.8%, P=0.009). Patients who were thyrotropin-receptor antibody (TRAb) positive after 12 Months of antithyroid therapy had a higher relapse rate than those who were negative (72.5% vs 36.8%, P<0.0001). Similarly, relapse was more frequent (55.5%) in patients having large goiter compared with subjects with small goiter (36.3%, P=0.0007). CONCLUSIONS: Relapse rates of Graves' disease were independent of ATD regimen whether followed by l-T(4) therapy or not. Smoking, large goiter and presence of TRAb at the end of ATD therapy were strong predictors of relapse.

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Metadata

Authors
Nedrebo, B., Holm, P., Uhlving, S., Sorheim, J., Skeie, S., Eide, G., Husebye, E., Lien, E., & Aanderud, S.
Affiliations
  • University of Bergen (NO)
  • Stord hospital (NO)
  • Haukeland University Hospital (NO)
ORCID
Skeie, S
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2002-11-01
Volume
147
Issue
5
Pages
583-589
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.0.1470583
OpenAlex
W2096392089
Cited by
132
References
29
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 4
FWCI
2.88
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Helse Vest
  • Norges Forskningsråd
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
Graves' disease, relapse prevention, antithyroid drugs, levothyroxine, TSH receptor antibodies, smoking, goiter size, predictors of relapse
MeSH terms
Antibodies, Drug Combinations, Graves Disease, Humans, Prognosis, Prospective Studies, Receptors, Thyrotropin, Smoking, Antithyroid Agents, Thyroxine, Treatment Outcome, Secondary Prevention

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