Cited by 350Thyroid Disorders and TreatmentsLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

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The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study

Åsvold, Bjørn O, Vatten, Lars J, Nilsen, Tom I L, Bjøro, Trine·2007·European Journal of Endocrinology

DOI 10.1530/eje.1.02333

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Abstract

Objective: The association between TSH and serum lipids in people with no apparent thyroid disease is insufficiently understood. We have studied the association between normal thyroid function, defined as TSH within the reference range of a general population, and concentrations of serum lipids. Design: Cross-sectional, population-based study with 30 656 individuals without known thyroid disease. Methods: Using general linear models, we calculated mean concentrations of total serum cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, HDL cholesterol and triglycerides across categories of TSH. Results: Within the reference range of TSH, there was a linear and significant (P for trend <0.001) increase in total serum cholesterol, LDL cholesterol, non-HDL cholesterol and triglycerides, and a linear decrease (P for trend <0.001) in HDL cholesterol with increasing TSH. Subgroup analyses showed statistically significant associations for all lipids in men above 50 years of age, and for triglycerides in all age groups. For women, associations were statistically significant in all age groups except for HDL cholesterol in women below 50 years of age. The associations with triglycerides and HDL cholesterol were stronger among overweight than normal weight individuals. Conclusions: Within the range of TSH that is considered clinically normal, we found that increasing level of TSH was associated with less favourable lipid concentrations. The association with serum lipids was linear across the entire reference range of TSH.

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Background
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Authors: Åsvold, B. O., Vatten, L. J., Nilsen, T. I. L., & Bjøro, T.
Affiliations: Norwegian University of Science and Technology (NO)
Oslo University Hospital (NO)
Corresponding author: Vatten, Lars J
ORCID: Vatten, Lars J
Nilsen, Tom I L
Bjøro, Trine
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2007-02
Volume: 156
Issue: 2
Pages: 181-186
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje.1.02333
OpenAlex: W2166928754
Cited by: 350
References: 21
Citations by year: 2026: 5 · 2025: 12 · 2024: 17 · 2023: 21 · 2022: 19 · 2021: 18 · 2020: 25 · 2019: 23 · 2018: 18 · 2017: 19 · 2016: 21 · 2015: 25 · 2014: 24 · 2013: 35 · 2012: 23
FWCI: 7.31
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Helse Midt-Norge
Norwegian Institute of Public Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: thyroid-stimulating hormone, serum lipids, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, non-HDL cholesterol, thyroid function, overweight, sex differences, age differences, HUNT study
MeSH terms: Adult, Aged, Cross-Sectional Studies, Female, Humans, Hyperlipidemias, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Obesity, Reference Values, Risk Factors, Thyroid Gland, Thyrotropin, Thyroxine, Triglycerides, Biomarkers, Linear Models, Age Distribution, Sex Distribution

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The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study

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