Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome
Open accessAbstract
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder affecting women of reproductive age. The origin of PCOS is still not clear and appears to be a function of gene x environment interactions. This review addresses the current knowledge of the genetic and developmental contributions to the etiology of PCOS, the ovarian and extra-ovarian mediators of PCOS and the gaps and key challenges that need to be addressed in the diagnosis, treatment and prevention of PCOS.
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Accruing evidence indicates that hyperandrogenism is a pivotal factor affecting multiple tissues in PCOS.
“The list of factors involved in the pathophysiology continues to expand, with accruing evidence indicating that hyperandrogenism is a pivotal factor affecting multiple tissues [220, 221].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [221]
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References 270 · Cited by 43
Research works printed but not linked: 5
- Albertini DF 2015 Chapter 2 - The Mammalian Oocyte. In Knobil and Neill’s Physiology of Reproduction (Fourth Edition), pp 59– 97. San Diego: Academic Press.
- Burns A, Cardoso RC, Puttabyatappa M, Herkimer C, Padmanabhan V 2016 Developmental programming: multigenerational effects of gestational exposure to excess testosterone on insulin sensitivity in female sheep Abstract Endocrine Society’s 98th Annual Meeting and Expo, April 1–4, 2016 Boston, MA 10.1210/endo-meetings.2016.RE.5.SUN-160. · DOI
- Escobar M, Vázquez-Nin G & Echeverría O 2011 Follicular Cells. In Cell Death in Mammalian Ovary, pp 185– 200: Springer Netherlands.
- Gill S & Hall JE 2014 The Hypothalamic–Pituitary Axis in PCOS. In Polycystic Ovary Syndrome, pp 81– 93: Springer.
- National Institues of Health 2012 Evidence-based Methodology Workshop on Polycystic Ovary Syndrome - Final Panel Report
- Authors
- Puttabyatappa, M., & Padmanabhan, V.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Padmanabhan, Vasantha
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2018-11
- Volume
- 61
- Issue
- 4
- Pages
- R161-R184
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- PMC
- PMC6192837
- OpenAlex
- W2810071465
- Cited by
- 43
- References
- 270
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 5
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Molecular Endocrinology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HD044232)
- National Institute of Environmental Health Sciences (P30ES017885)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD044232)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, PCOS etiology, gene-environment interaction, genetic contribution, PCOS diagnosis, PCOS treatment, PCOS prevention
- MeSH terms
- Animals, Female, Granulosa Cells, Humans, Insulin, Ovary, Polycystic Ovary Syndrome
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