miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas
Abstract
miR-23a-3p and miR-23b-3p are members of the miR-23~27~24-2 superfamily. The role of miR-23a/b-3p in regulating hepatic lipid accumulation is still unknown. Here, we found that increased miR-23a-3p and miR-23b-3p levels were accompanied by an increase in the protein levels of the sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the steatotic livers of mice fed a high-fat diet and leptin receptor-deficient type 2 diabetic mice (db/db). Importantly, overexpression of miR-23a/b-3p in Hep1-6 cells elevated the intracellular triglyceride level and upregulated the expression of Srebp-1c and Fas. Taken together, these results suggested that miR-23a/b-3p enhanced mRNA stability by binding the 5'-UTR of Srebp-1c and Fas mRNA, thereby promoting triglyceride accumulation in hepatocytes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Overexpression of miR-23a-3p in Hep1-6 cells of db/db mice can up-regulate SREBP-1 and FAS, leading to accumulation of triglycerides in hepatocytes.
“Furthermore, overexpression of miR-23a-3p in Hep1-6 cells of db/db mice can up-regulate the expression of sterol regulatory element binding protein-1 (SREBP-1) and fatty acid synthase (FAS), leading to an accumulation of triglycerides in hepatocytes.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [21]
Overexpression of miR-23a-3p drives proliferation of lipid-associated macrophages in obese adipose tissue and prevents diet-induced obesity metabolic dysfunction.
“This also drives the proliferation of lipid-associated macrophages in obese adipose tissue and prevents diet-induced obesity metabolic dysfunction [21,22].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [21]
Cited by
Sorted by citations
Recent advances of miR-23 in human diseases and growth development
Qian, X., Jiang, Y., Yang, Y., Zhang, Y., Xu, N., Xu, B., Pei, K., Yu, Z., & Wu, W. (2025) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.12.010 · Cited by 5 · see citing works
- Authors
- Li, L., Zhang, X., Ren, H., Huang, X., Shen, T., Tang, W., Dou, L., & Li, J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- ORCID
- Dou, Lin
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2022-01-01
- Volume
- 68
- Issue
- 1
- Pages
- 35-49
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W3211042277
- Cited by
- 38
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 14 · 2023: 12 · 2022: 2 · 2021: 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- miR-23a-3p, miR-23b-3p, hepatic lipid accumulation, SREBP-1c, fatty acid synthase, steatosis, triglyceride accumulation, high-fat diet, db/db mice, leptin receptor deficiency, type 2 diabetes, mRNA stability, hepatocytes
- MeSH terms
- Animals, Disease Susceptibility, Gene Expression Regulation, Liver, Male, Triglycerides, 5' Untranslated Regions, Hepatocytes, RNA Interference, MicroRNAs, Lipid Metabolism, Mice, Sterol Regulatory Element Binding Protein 1, Fatty Acid Synthase, Type I, Diet, High-Fat, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
