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Mast cell degranulation in rat uterine cervix during pregnancy correlates with expression of vascular endothelial growth factor mRNA and angiogenesis.
Open accessAbstract
Vascular growth of the uterine cervix during pregnancy is associated with mast cell (MC) degranulation. To better understand the mechanism underlying this process, uterine cervices of intact pregnant rats were dissected and endothelial cell proliferation was measured by a bromodeoxyuridine incorporation technique. Total vascular endothelial growth factor (VEGF) mRNA expression and the relative abundance of VEGF splice variants (120, 164, and 188) were determined by RT-PCR. VEGF protein expression was evaluated by immunohistochemistry. To investigate the role of MCs on cervical angiogenesis, a second set of pregnant animals were treated with an MC stabilizer (disodium cromoglycate) to inhibit MC degranulation. Furthermore, 17beta-estradiol (E(2)) serum levels were established by RIA. In intact pregnant rats, VEGF mRNA expression was positively correlated with endothelial cell proliferation and circulating E(2) levels. All selected splice variants of VEGF gene were detected and their relative abundance did not show any change throughout pregnancy. Animals treated with disodium cromoglycate showed a decrease in endothelial cell proliferation and in VEGF mRNA expression compared with controls. Relative abundance of VEGF mRNA splice variants and E(2) serum levels showed no differences between these experimental groups. These results show a time-dependent correlation between VEGF mRNA expression and E(2) serum levels in the uterine cervix of intact pregnant rats, while MC stabilizer-treated animals reduced the VEGF expression without modifying E(2) serum levels. We suggest that cervical angiogenesis during pregnancy could be regulated by a mechanism which involves endogenous E(2) and chemical mediators stored in MC granules via a VEGF-dependent pathway.
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“their degranulation causes the release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in the attachment and posterior invasion of the embryo into the uterus.”
From Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation (2010) · cites this paper as [47]
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“Moreover, the proangiogenic factor VEGF released from MCs after MC degranulation was implied as a key regulator on this process [47].”
From Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation (2010) · cites this paper as [47]
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“Moreover, MC degranulation correlates with angiogenesis during pregnancy.”
From Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation (2010) · cites this paper as [47]
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References 57 · Cited by 35
Research works printed but not linked: 9
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- 1986, Immunology, 58, 101
- 1998, Laboratory Investigation, 78, 1385
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- 1996, Cancer Research, 56, 3954
- 2000, Cancer Research, 60, 3183
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- 2003, Brazilian Journal of Morphological Sciences, 20, 75
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Metadata
- Authors
- Bosquiazzo, V. L., Ramos, J. G., Varayoud, J., Muñoz-de-Toro, M., & Luque, E. H.
- Affiliations
- Universidad Nacional del Litoral (AR)
- Laboratorio de Endocrinología y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Casilla de Correo 242, 3000 Santa Fe, Argentina
- Corresponding author
- Luque, E H
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-01
- Volume
- 133
- Issue
- 5
- Pages
- 1045-1055
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2164180992
- Cited by
- 35
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- National Academy of Sciences
- Agencia Nacional de Promoción Científica y Tecnológica (CONICET)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
- Keywords
- mast cell degranulation, uterine cervix, vascular endothelial growth factor, VEGF splice variants, endothelial cell proliferation, estradiol, disodium cromoglycate, pregnancy, vascular development
- MeSH terms
- Animals, Cervix Uteri, Cromolyn Sodium, Estradiol, Female, Immunohistochemistry, Mast Cells, Pregnancy, Pregnancy, Animal, RNA, Messenger, Cell Degranulation, Rats, Wistar, Alternative Splicing, Neovascularization, Physiologic, Reverse Transcriptase Polymerase Chain Reaction, Vascular Endothelial Growth Factor A, Cell Proliferation, Rats
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- CoChat. (2026). Citation check: Mast cell degranulation in rat uterine cervix during pregnancy correlates with expression of vascular endothelial growth factor mRNA and angiogenesis. https://app.cochat.ai/papers/10.1530/rep-06-0168
- The paper
- Bosquiazzo, V. L., Ramos, J. G., Varayoud, J., Muñoz-de-Toro, M., & Luque, E. H. (2007). Mast cell degranulation in rat uterine cervix during pregnancy correlates with expression of vascular endothelial growth factor mRNA and angiogenesis. Reproduction. https://doi.org/10.1530/rep-06-0168
