The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Ovarian follicular cells have innate immune capabilities that modulate their endocrine function
Open accessAbstract
Oestrogens are pivotal in ovarian follicular growth, development and function, with fundamental roles in steroidogenesis, nurturing the oocyte and ovulation. Infections with bacteria such as Escherichia coli cause infertility in mammals at least in part by perturbing ovarian follicle function, characterised by suppression of oestradiol production. Ovarian follicle granulosa cells produce oestradiol by aromatisation of androstenedione from the theca cells, under the regulation of gonadotrophins such as FSH. Many of the effects of E. coli are mediated by its surface molecule lipopolysaccharide (LPS) binding to the Toll-like receptor-4 (TLR4), CD14, MD-2 receptor complex on immune cells, but immune cells are not present inside ovarian follicles. The present study tested the hypothesis that granulosa cells express the TLR4 complex and LPS directly perturbs their secretion of oestradiol. Granulosa cells from recruited or dominant follicles are exposed to LPS in vivo and when they were cultured in the absence of immune cell contamination in vitro they produced less oestradiol when challenged with LPS, although theca cell androstenedione production was unchanged. The suppression of oestradiol production by LPS was associated with down-regulation of transcripts for aromatase in granulosa cells, and did not affect cell survival. Furthermore, these cells expressed TLR4, CD14 and MD-2 transcripts throughout the key stages of follicle growth and development. It appears that granulosa cells have an immune capability to detect bacterial infection, which perturbs follicle steroidogenesis, and this is a likely mechanism by which ovarian follicle growth and function is perturbed during bacterial infection.
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Cites
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Self-citation
Cited by
Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications
Da Broi, M. G., Giorgi, V. S. I., Wang, F., Keefe, D. L., Albertini, D., & Navarro, P. A. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1143-3 · Cited by 312
Evaluation of inflammation and follicle depletion during ovarian ageing in mice
Lliberos, C., Liew, S. H., Zareie, P., La Gruta, N. L., Mansell, A., & Hutt, K. (2021) · Scientific Reports · doi:10.1038/s41598-020-79488-4 · Cited by 247
Physiological consequences of heat stress in pigs
Ross, J. W., Hale, B. J., Gabler, N. K., Rhoads, R. P., Keating, A. F., & Baumgard, L. H. (2015) · Animal Production Science · doi:10.1071/an15267 · Cited by 202
Physiological mechanisms through which heat stress compromises reproduction in pigs
Ross, J. W., Hale, B. J., Seibert, J. T., Romoser, M. R., Adur, M. K., Keating, A. F., & Baumgard, L. H. (2017) · Molecular Reproduction and Development · doi:10.1002/mrd.22859 · Cited by 128
Yan, K., Zhu, W., Yu, L., Li, N., Zhang, X., Liu, P., Chen, Q., Chen, Y., & Han, D. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.027 · Cited by 26
Metadata
- Authors
- Herath, S., Williams, E. J., Lilly, S. T., Gilbert, R. O., Dobson, H., Bryant, C. E., & Sheldon, I. M.
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-01
- Volume
- 134
- Issue
- 5
- Pages
- 683-693
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2139437936
- Cited by
- 342
- References
- 45
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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