Endometriosis: where are we and where are we going?
Open accessAbstract
Endometriosis currently affects ~5.5 million reproductive-aged women in the U.S. with symptoms such as painful periods (dysmenorrhea), chronic pelvic pain, pain with intercourse (dyspareunia), and infertility. It is defined as the presence of endometrial tissue outside the uterine cavity and is found predominately attached to sites within the peritoneal cavity. Diagnosis for endometriosis is solely made through surgery as no consistent biomarkers for disease diagnosis exist. There is no cure for endometriosis and treatments only target symptoms and not the underlying mechanism(s) of disease. The nature of individual predisposing factors or inherent defects in the endometrium, immune system, and/or peritoneal cavity of women with endometriosis remains unclear. The literature over the last 5 years (2010–2015) has advanced our critical knowledge related to hormones, hormone receptors, immune dysregulation, hormonal treatments, and the transformation of endometriosis to ovarian cancer. In this review, we cover the aforementioned topics with the goal of providing the reader an overview and related references for further study to highlight the progress made in endometriosis research, while concluding with critical areas of endometriosis research that are urgently needed.
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References 195 · Cited by 187
Research works printed but not linked: 1
- [104]104. Wei JJ, William J & Bulun S 2011 Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects. International R78 A D Greene and others Reproduction (2016) 152 R63-R78 www.reproduction-online.org Journal of Gynecological Pathology 30 553-568. (doi:10.1097/ PGP.0b013e31821f4b85)
- Authors
- Greene, A. D., Lang, S. A., Kendziorski, J. A., Sroga-Rios, J. M., Herzog, T. J., & Burns, K. A.
- Affiliations
- University of Cincinnati (US)
- Department of Environmental Health University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
- Corresponding author
- Burns, Katherine A
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-09-01
- Volume
- 152
- Issue
- 3
- Pages
- R63-R78
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- PMC
- PMC4958554
- OpenAlex
- W2371764543
- Cited by
- 187
- References
- 195
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 13 · 2023: 24 · 2022: 24 · 2021: 25 · 2020: 35 · 2019: 11 · 2018: 18 · 2017: 20
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Cincinnati
- Chinese Medical Association
- College of Medicine, University of Cincinnati
- National Institute of Environmental Health Sciences (R00ES021737)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, endometriosis diagnosis, immune dysregulation, hormone receptors, hormone therapy, endometriosis-associated ovarian cancer, endometrium, peritoneal cavity
- MeSH terms
- Endometriosis, Female, Humans
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