Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegans
Open accessAbstract
We have achieved targeted heritable genome modification in Caenorhabditis elegans by injecting mRNA of the nuclease Cas9 and Cas9 guide RNAs. This system rapidly creates precise genomic changes, including knockouts and transgene-instructed gene conversion.
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The CRISPR/Cas system has been successfully applied to human cells and several model organisms for genome editing.
“Recently, the CRISPR/Cas system has been successfully applied to human cells19,20,21,22 and several model organisms for genome editing.23,24,25,26”
From The CRISPR/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo (2014) · cites this paper as [25]
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References 37 · Cited by 95
- Authors
- Katic, I., & Großhans, H.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Katic, Iskra
- Großhans, Helge
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11-01
- Volume
- 195
- Issue
- 3
- Pages
- 1173-1176
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC3813846
- OpenAlex
- W2113742465
- Cited by
- 95
- References
- 37
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 10 · 2015: 16 · 2014: 28 · 2013: 9
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (P40 OD010440, SNF 31003A_143313)
- Friedrich Miescher Institute for Biomedical Research
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (42250, 143313)
- National Institutes of Health (OD010440, P40OD010440)
- FP7 Ideas: European Research Council (241985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- Cas9, CRISPR, gene conversion, targeted mutagenesis, Caenorhabditis elegans, mRNA injection, guide RNA, transgene integration
- MeSH terms
- Animals, Base Sequence, Gene Conversion, Calcium Channels, Caenorhabditis elegans, Genes, Helminth, RNA Editing, Germ-Line Mutation, Gene Targeting, RNA, Helminth, Caenorhabditis elegans Proteins, Animals, Genetically Modified, DNA Breaks, Double-Stranded, Gene Knockout Techniques, CRISPR-Cas Systems
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