Comparative treatment efficiency of adipose and bone marrow derived allogenic mesenchymal stem cell transplantation in mouse models of liver fibrosis
Open accessAbstract
Background: The application of mesenchymal stem cell (MSC) therapy in liver fibrosis treatment has been increasingly investigated in recent years. MSCs obtained from a variety of sources (e.g. bone marrow, umbilical cord blood and adipose tissue) have been studied and have achieved remarkable results. In this study, we compared the effects of adipose-derived mesenchymal stem cells (AD-MSC) transplantation with bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation in a mouse model of liver fibrosis, induced by carbon tetrachloride (CCl4). Methods: Eight-week old mice were treated with CCl4 for 11 weeks to induce liver fibrosis then 5x105 cells were transplanted into mice via the tail vein. Results: After 21 days of transplantation, the results showed that the stem cell treated groups ameliorated better than the placebo group. MSC treated groups showed reduced AST and ALT levels, down-regulated expression of extracellular matrix (ECM) genes, and improved liver histopathology. Both sources of MSCs (bone marrow and adipose tissue) were effective in the mouse model of liver fibrosis. Conclusion: Our results also indicated that AD-MSC transplantation in mice accelerated liver regeneration better than BM-MSC transplantation.
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AD-MSCs were more effective than BM-MSCs in ameliorating liver fibrosis in mouse models, as reflected by superior reduction in AST and ALT, fibrotic gene expression, and enhanced regeneration.
“Nguyen et al. provided direct evidence that AD-MSCs were more effective than BM-MSCs in ameliorating liver fibrosis in mouse models, as reflected by superior reduction in AST and ALT, fibrotic gene expression, and enhanced regeneration [318].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [318]
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Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
- Authors
- Nguyen, N. H., Le, T. V., Do, H. Q., Ngo, D. Q., Le, H. M., & Truong, N. H.
- Affiliations
- Vietnam National University Ho Chi Minh City (VN)
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- Corresponding author
- Truong, Nhung Hai
- Venue
- Biomedical Research and Therapy
- Publisher
- Biomedpress
- Published
- 2017-06-25
- Volume
- 4
- Issue
- 06
- Pages
- 1374
- ISSN
- 2198-4093 (ISSN-L)
- OpenAlex
- W2681911385
- Cited by
- 7
- References
- 0
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Biomedical Research and Therapy (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- mesenchymal stem cells, liver fibrosis, adipose-derived stem cells, bone marrow-derived stem cells, allogeneic stem cell transplantation, carbon tetrachloride-induced liver injury, extracellular matrix genes, liver regeneration, stem cell source comparison
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