The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Long-Term Prognosis for Childhood Constipation: Clinical Outcomes in Adulthood
Abstract
OBJECTIVES: This study examines long-term prognoses for children with constipation in adulthood and identifies prognostic factors associated with clinical outcomes. METHODS: In a Dutch tertiary hospital, children (5–18 years of age) who were diagnosed as having functional constipation were eligible for inclusion. After a 6-week treatment protocol, prospective follow-up evaluations were conducted at 6 and 12 months and annually thereafter. Good clinical outcomes were defined as ≥3 bowel movements per week for ≥4 weeks, with ≤2 fecal incontinence episodes per month, irrespective of laxative use. RESULTS: A total of 401 children (260 boys; median age: 8 years [interquartile range: 6–9 years]) were included, with a median follow-up period of 11 years (interquartile range: 9–13 years). The dropout rate during follow-up was 15%. Good clinical outcomes were achieved by 80% of patients at 16 years of age. Thereafter, this proportion remained constant at 75%. Poor clinical outcomes at adult age were associated with: older age at onset (odds ratio [OR]: 1.15 [95% confidence interval [CI]: 1.02–1.30]; P = .04), longer delay between onset and first visit to our outpatient clinic (OR: 1.24 [95% CI: 1.10–1.40]; P = .001), and lower defecation frequency at study entry (OR: 0.92 [95% CI: 0.84–1.00]; P = .03). CONCLUSIONS: One-fourth of children with functional constipation continued to experience symptoms at adult age. Certain risk factors for poor clinical outcomes in adulthood were identified. Referral to a specialized clinic should be considered at an early stage for children who are unresponsive to first-line treatment.
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Myths and Misconceptions About Chronic Constipation
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Childhood constipation: longitudinal follow-up beyond puberty
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Self-citationChronic constipation in children
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Chronic Childhood Constipation Is Associated with Impaired Quality of Life: A Case‐Controlled Study
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Prevalence, symptoms and outcome of constipation in infants and toddlers
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Biofeedback training in treatment of childhood constipation: a randomised controlled study
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Management of functional constipation in children and adults
Vriesman, M. H., Koppen, I. J. N., Camilleri, M., Di Lorenzo, C., & Benninga, M. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0222-y · Cited by 457
Self-citationAssociation of Constipation and Fecal Incontinence With Attention-Deficit/Hyperactivity Disorder
McKeown, C., Hisle-Gorman, E., Eide, M., Gorman, G. H., & Nylund, C. M. (2013) · Pediatrics · doi:10.1542/peds.2013-1580 · Cited by 134
Nonpharmacologic treatments for childhood constipation: systematic review
Tabbers, M. M., Boluyt, N., Berger, M. Y., & Benninga, M. A. (2011) · Pediatrics · doi:10.1542/peds.2011-0179 · Cited by 95
Self-citationCollis, D., Kennedy‐Behr, A., & Kearney, L. (2019) · Child: Care, Health and Development · doi:10.1111/cch.12620 · Cited by 70
Long‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy
Bonilla, S., Nurko, S., & Rodriguez, L. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002795 · Cited by 36
Metadata
- Authors
- Bongers, M. E. J., van Wijk, M. P., Reitsma, J. B., & Benninga, M. A.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2010-07-01
- Volume
- 126
- Issue
- 1
- Pages
- e156-e162
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2147995336
- Cited by
- 264
- References
- 28
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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