The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Off-Label Use of Drugs in Children
Abstract
The passage of the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act has collectively resulted in an improvement in rational prescribing for children, including more than 800 labeling changes. However, off-label drug use remains an important public health issue for infants, children, and adolescents, because an overwhelming number of drugs still have no information in the labeling for use in pediatrics. The purpose of off-label use is to benefit the individual patient. Practitioners use their professional judgment to determine these uses. As such, the term “off-label” does not imply an improper, illegal, contraindicated, or investigational use. Therapeutic decision-making must always rely on the best available evidence and the importance of the benefit for the individual patient.
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Citations
Cites
Pediatric Drug Labeling: Improving the Safety and Efficacy of Pediatric Therapies
Roberts, R., Rodriguez, W., Murphy, D., & Crescenzi, T. (2003) · JAMA · doi:10.1001/jama.290.7.905 · Cited by 299
Off-label Drug Use in Hospitalized Children
Shah, S. S., Hall, M., Goodman, D. M., Feuer, P., Sharma, V., Fargason, C., Hyman, D., Jenkins, K., White, M. L., Levy, F. H., et al. (2007) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.161.3.282 · Cited by 221
Testing Medications in Children
Steinbrook, R. (2002) · New England Journal of Medicine · doi:10.1056/nejmhpr021646 · Cited by 207
Pediatric Information in Drug Product Labeling
Avant, D. (2012) · JAMA · doi:10.1001/jama.2012.3435 · Cited by 132
Uses of Drugs Not Described in the Package Insert (Off-Label Uses)
Committee on Drugs (2002) · PEDIATRICS · doi:10.1542/peds.110.1.181 · Cited by 96
Self-citation
Cited by
Drug Shortage: Causes, Impact, and Mitigation Strategies
Shukar, S., Zahoor, F., Hayat, K., Saeed, A., Gillani, A. H., Omer, S., Hu, S., Babar, Z.-U.-D., Fang, Y., & Yang, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.693426 · Cited by 322
Barrett, J. S., Bishai, R., Bucci‐Rechtweg, C., Cheung, A., Corriol‐Rohou, S., Haertter, S., James, A., Kovacs, S. J., Liu, J., Potempa, D., et al. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1000 · Cited by 38
Metadata
- Authors
- COMMITTEE ON DRUGS, Neville, K. A., Frattarelli, D. A. C., Galinkin, J. L., Green, T. P., Johnson, T. D., MMM, Paul, I. M., & Van Den Anker, J. N.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2014-03-01
- Volume
- 133
- Issue
- 3
- Pages
- 563-567
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W3098185024
- Cited by
- 391
- References
- 5
- FWCI
- 27.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Off-Label Use of Drugs in Children. https://app.cochat.ai/papers/10.1542/peds.2013-4060
- The paper
- COMMITTEE ON DRUGS, Neville, K. A., Frattarelli, D. A. C., Galinkin, J. L., Green, T. P., Johnson, T. D., MMM, Paul, I. M., & Van Den Anker, J. N. (2014). Off-Label Use of Drugs in Children. Pediatrics. https://doi.org/10.1542/peds.2013-4060
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
