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Cited by 46Neonatal Health and BiochemistryPediatric Hepatobiliary Diseases and TreatmentsMaternal and Neonatal Healthcare

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Predicting Nonhemolytic Neonatal Hyperbilirubinemia

Norman, Mikael, Åberg, Katarina, Holmsten, Karin, Weibel, Vania, Ekéus, Cecilia·2015·Pediatrics
DOI 10.1542/peds.2015-2001
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Abstract

Background Before hospital discharge, newborn infants should be assessed for the risk of excessive hyperbilirubinemia. We determined maternal and obstetric risk factors for hyperbilirubinemia in infants born at term (gestational age ≥37 weeks) to form an individualized risk assessment tool for clinical use. Methods This was a population-based study with data from the Swedish Medical Birth Register from 1999 to 2012, including 1,261,948 singleton infants. Outcome was defined as infants diagnosed with hyperbilirubinemia (N = 23,711), excluding all cases of hemolytic (immune-mediated or other specified hemolytic) diseases of the newborn. Results Risk factors with an adjusted odds ratio (aOR) for neonatal hyperbilirubinemia of ≥1.5 (medium-sized effect or more) were gestational age 37 to 38 weeks (aOR = 2.83), failed vacuum extraction (aOR = 2.79), vacuum extraction (aOR = 2.22), Asian mother (aOR = 2.09), primipara (aOR = 2.06), large-for-gestational-age infant (aOR = 1.84), obese mother (aOR = 1.83), and small-for-gestational-age infant (aOR = 1.66). Planned cesarean delivery (CD) was associated with a reduced risk (aOR = 0.45). Without any of these risk factors (normal birth weight infant delivered vaginally at 39 to 41 weeks' gestation by a non-Asian, nonobese, multiparous mother) the rate of nonhemolytic neonatal hyperbilirubinemia was 0.7%. In relation to the combined load of different risk factors, rates of neonatal hyperbilirubinemia ranged from 0.2% to 25%. Conclusions C…

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Metadata

Authors
Norman, M., Åberg, K., Holmsten, K., Weibel, V., & Ekéus, C.
Affiliations
  • Karolinska University Hospital (SE)
  • Karolinska Institutet (SE)
  • IVF Clinic Umeå, IVF Sweden AB, Umeå, Sweden
  • Department of Obstetrics and Gynecology,
Corresponding author
Norman, Mikael
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2015-12-01
Volume
136
Issue
6
Pages
1087-1094
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2015-2001
OpenAlex
W2288421299
Cited by
46
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 4
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
  • Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
Keywords
risk prediction, maternal risk factors, prenatal risk factors, term infants, gestational age, vacuum extraction, cesarean section, maternal obesity, primiparity, elective cesarean section, individual risk assessment
MeSH terms
Adult, Female, Humans, Infant, Newborn, Male, Mothers, Pregnancy, Pregnancy Complications, Registries, Risk Factors, Sweden, Incidence, Risk Assessment, Hyperbilirubinemia, Neonatal

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