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Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: Clinical Report
Open accessAbstract
Therapeutic hypothermia to a temperature of 33.5 to 34.5 °C initiated within 6 hours of birth and continued for 72 hours reduces the risk of death or moderate-to-severe neurodevelopmental impairments in neonates with moderate-to-severe hypoxic-ischemic encephalopathy (HIE) born at ≥36 0/7 weeks of gestation. This specialized therapy requires neuromonitoring, neuroimaging, and plans for follow-up of neurodevelopmental outcomes. Any center or practitioner involved in newborn deliveries should have action plans for prompt recognition and initiation of therapeutic hypothermia or transfer of infants with possible HIE to a center providing therapeutic hypothermia. Because many neonates with HIE are born at places that do not provide therapeutic hypothermia, therapeutic hypothermia centers should work with their referring hospitals, birthing centers and practitioners to implement educational programs that focus on the identification, initial clinical management of affected neonates, and prompt transfer of neonates with moderate-to-severe HIE.
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Therapeutic hypothermia (TH) is standard of care for infants diagnosed with moderate to severe HIE.
“Therapeutic hypothermia (TH) is standard of care for infants diagnosed with moderate to severe HIE (2).”
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References 108 · Cited by 26
Research works printed but not linked: 2
- Gano, 2014, Neonatal seizures and therapeutic hypothermia for hypoxic-ischemic encephalopathy, Mol Cell Epilepsy., 1, e88
- Robertson, 2006, Follow-up of the term infant after hypoxic-ischemic encephalopathy, Paediatr Child Health., 11, 278
Metadata
- Authors
- Zanelli, S. A., Wusthoff, C. J., Lucke, A. M., Kaufman, D. A., Committee on Fetus and Newborn, Eichenwald, E., Ambalavanan, N., Guillory, C., Hudak, M., Kaufman, D., Martin, C., Lucke, A., Parker, M., Pramanik, A., Wade, K., Neurology, S. O., Lotze, T. E., Capal, J. K., DiGiovine, M., Lewis, D., Shellhaas, R. A., & Wusthoff, C. J.
- Affiliations
- University of Virginia Medical Center (US)
- 3Department of Pediatrics, Division of Neonatology, University of Texas, Austin, Texas
- 1Department of Pediatrics, Division of Neonatology, University of Virginia School of Medicine, Charlottesville, Virginia
- Corresponding author
- Zanelli, Santina A.
- ORCID
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2026-01-26
- Volume
- 157
- Issue
- 2
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W7125639083
- Cited by
- 26
- References
- 108
- Citations by year
- 2026: 26
- FWCI
- 265.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- therapeutic hypothermia, neonatal hypoxic-ischemic encephalopathy, neuroprotection, neurodevelopmental outcomes, neonatal intensive care, neonatal transport, gestational age
- MeSH terms
- Female, Humans, Hypothermia, Induced, Infant, Newborn, Male, Hypoxia-Ischemia, Brain
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