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CENTRAL AUTONOMIC DYSFUNCTION WITH DEFECTIVE LACRIMATION
Abstract
Five cases have been reported with symptoms and findings so similar as to constitute a clinical entity. The common features in this group are: 1. a deficiency of lacrimation; 2. an abnormal reaction to mild anxiety characterized by transient extreme elevation of blood pressure, excessive sweating, salivation to the point of drooling, and the development of sharply demarcated erythematous blotches on the skin, biliterally symmetric, and tending to recur in the same or similar configurations. The findings seem best interpreted as a central, possibly congenital, disturbance of autonomic function. An origin in the diencephalon has been suggested. The most difficult feature to interpret from a neurophysiologic point of view is diminished rather than excessive lacrimation.
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Citations
Cited by
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Slaugenhaupt, S. A., Blumenfeld, A., Gill, S. P., Leyne, M., Mull, J., Cuajungco, M. P., Liebert, C. B., Chadwick, B., Idelson, M., Reznik, L., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318810 · Cited by 591
Holly, F. J., & Lemp, M. A. (1977) · Survey of Ophthalmology · doi:10.1016/0039-6257(77)90087-x · Cited by 559
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Anderson, S. L., Coli, R., Daly, I. W., Kichula, E. A., Rork, M. J., Volpi, S. A., Ekstein, J., & Rubin, B. Y. (2001) · The American Journal of Human Genetics · doi:10.1086/318808 · Cited by 428
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Metadata
- Authors
- RILEY, C. M., DAY, R. L., GREELEY, D. M., & LANGFORD, W. S.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1949-04-01
- Volume
- 3
- Issue
- 4
- Pages
- 468-478
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W4206653560
- Cited by
- 332
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CENTRAL AUTONOMIC DYSFUNCTION WITH DEFECTIVE LACRIMATION. https://app.cochat.ai/papers/10.1542/peds.3.4.468
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- RILEY, C. M., DAY, R. L., GREELEY, D. M., & LANGFORD, W. S. (1949). CENTRAL AUTONOMIC DYSFUNCTION WITH DEFECTIVE LACRIMATION. Pediatrics. https://doi.org/10.1542/peds.3.4.468
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
