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Outcome of Symptomatic Congenital Cytomegalovirus Infection: Results of Long-Term Longitudinal Follow-up
Abstract
Thirty-four patients with congenital cytomegalovirus infection who were symptomatic as newborns were followed in a special clinic providing periodic medical and visual examinations as well as psychometric testing and audiometry. All patients had symptoms of congenital infection by 2 weeks of age, and 31 of 34 had virus isolated from urine within the first month of life. Age at latest follow-up varied from 9 months to 14 years with a mean of about 4 years. Ten patients died and 23 surviving patients had adequate follow-up examinations; all but two had evidence of central nervous system or auditory handicaps. Microcephaly was present in 16 (70%), mental retardation in 14 (61%), hearing loss in seven (30%), neuromuscular disorders in eight (35%), and chorioretinitis or optic atrophy in five (22%). Children with symptomatic congenital cytomegalovirus infection are at very high risk for handicaps that will significantly impair development.
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Citations
Cited by
Dollard, S. C., Grosse, S. D., & Ross, D. S. (2007) · Reviews in Medical Virology · doi:10.1002/rmv.544 · Cited by 1,257
The Outcome of Congenital Cytomegalovirus Infection in Relation to Maternal Antibody Status
Fowler, K. B., Stagno, S., Pass, R. F., Britt, W. J., Boll, T. J., & Alford, C. A. (1992) · New England Journal of Medicine · doi:10.1056/nejm199203053261003 · Cited by 1,084
Self-citationHearing Loss and Congenital CMV Infection: A Systematic Review
Goderis, J., De Leenheer, E., Smets, K., Van Hoecke, H., Keymeulen, A., & Dhooge, I. (2014) · Pediatrics · doi:10.1542/peds.2014-1173 · Cited by 586
MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a
Fu, Y.-R., Liu, X.-J., Li, X.-J., Shen, Z.-Z., Yang, B., Wu, C.-C., Li, J.-F., Miao, L.-F., Ye, H.-Q., Qiao, G.-H., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01740-14 · Cited by 69
Metadata
- Authors
- Pass, R. F., Stagno, S., Myers, G. J., & Alford, C. A.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1980-11-01
- Volume
- 66
- Issue
- 5
- Pages
- 758-762
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1647519295
- Cited by
- 435
- References
- 0
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Outcome of Symptomatic Congenital Cytomegalovirus Infection: Results of Long-Term Longitudinal Follow-up. https://app.cochat.ai/papers/10.1542/peds.66.5.758
- The paper
- Pass, R. F., Stagno, S., Myers, G. J., & Alford, C. A. (1980). Outcome of Symptomatic Congenital Cytomegalovirus Infection: Results of Long-Term Longitudinal Follow-up. Pediatrics. https://doi.org/10.1542/peds.66.5.758
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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