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Nature and Rates of Adverse Reactions Associated with DTP and DT Immunizations in Infants and Children
Abstract
In 784 DT and 15,752 DTP immunizations given to children 0 to 6 years of age who were prospectively studied for reactions occurring within 48 hours following immunization, minor reactions were significantly more frequent following DTP vaccine. The ratio of reaction rates associated with DTP and DT immunizations (DTP/DT) for selected local and systemic reactions was as follows: local redness, 37.4%/7.6%; local swelling, 40.7%/7.6%; pain, 50.9%/9.9%; fever, 31.5%/14.9%; drowsiness, 31.5%/14.9%; fretfulness, 53.4%/22.6%; vomiting, 6.2%/2.6%; anorexia, 20.9%/7.0% and persistent crying, 3.1%/0.7%. Following DTP immunization nine children developed convulsions and nine developed hypotonic hyporesponsive episodes. No sequelae were detected following these reactions.
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Cited by
Liang, J. L., Tiwari, T., Moro, P., Messonnier, N. E., Reingold, A., Sawyer, M., & Clark, T. A. (2018) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6702a1 · Cited by 457
Pertussis: Microbiology, Disease, Treatment, and Prevention
Kilgore, P. E., Salim, A. M., Zervos, M. J., & Schmitt, H.-J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00083-15 · Cited by 434
Meszaros, J. R., Asch, D. A., Baron, J., Hershey, J. C., Kunreuther, H., & Schwartz-Buzaglo, J. (1996) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(96)00007-8 · Cited by 271
Communicating science to the public: MMR vaccine and autism
Offit, P. A., & Coffin, S. E. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00532-2 · Cited by 113
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(2007) · New England Journal of Medicine · doi:10.1056/nejmoa054960 · Cited by 90
Metadata
- Authors
- Cody, C. L., Baraff, L. J., Cherry, J. D., Marcy, S. M., & Manclark, C. R.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1981-11-01
- Volume
- 68
- Issue
- 5
- Pages
- 650-660
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1516456315
- Cited by
- 536
- References
- 0
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cody, C. L., Baraff, L. J., Cherry, J. D., Marcy, S. M., & Manclark, C. R. (1981). Nature and Rates of Adverse Reactions Associated with DTP and DT Immunizations in Infants and Children. Pediatrics. https://doi.org/10.1542/peds.68.5.650
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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