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`Like a Shrivelled Blood Orange'—Bilirubin, Jaundice, and Phototherapy
Abstract
The biochemistry of bilirubin is reviewed with particular reference to newborn infants. The formation, properties, and metabolism of bilirubin are summarized and the importance of molecular shape, hydrogen-bonding, and polarity on the biologic disposition of bilirubin is emphasized. The chemical basis for the subtle influence of visible (blue) light on bilirubin structure and metabolism is explained, and recent concepts of the mechanism of phototherapy are presented. A glossary of current jargon is appended.
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Citations
Cited by
Bilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 2,948
Self-citationPharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115
Different Faces of the Heme-Heme Oxygenase System in Inflammation
Wagener, F. A. D. T. G., Volk, H.-D., Willis, D., Abraham, N. G., Soares, M. P., Adema, G. J., & Figdor, C. G. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.5 · Cited by 537
Iyanagi, T. (2007) · International Review of Cytology · doi:10.1016/s0074-7696(06)60002-8 · Cited by 290
Metadata
- Authors
- McDonagh, A. F., & Lightner, D. A.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1985-03-01
- Volume
- 75
- Issue
- 3
- Pages
- 443-455
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2117522152
- Cited by
- 192
- References
- 0
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: `Like a Shrivelled Blood Orange'—Bilirubin, Jaundice, and Phototherapy. https://app.cochat.ai/papers/10.1542/peds.75.3.443
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- McDonagh, A. F., & Lightner, D. A. (1985). `Like a Shrivelled Blood Orange'—Bilirubin, Jaundice, and Phototherapy. Pediatrics. https://doi.org/10.1542/peds.75.3.443
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
