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Extracorporeal Membrane Oxygenation and Conventional Medical Therapy in Neonates With Persistent Pulmonary Hypertension of the Newborn: A Prospective Randomized Study
Abstract
Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which extracorporeal membrane oxygenation (ECMO) therapy was compared with conventional medical therapy (CMT). In phase I, 4 of 10 babies in the CMT group died and 9 of 9 babies in the ECMO group survived. Randomization was halted after the fourth CMT death, as planned before initiating the study, and the next 20 babies were treated with ECMO (phase II). Of the 20, 19 survived. All three treatment groups (CMT and ECMO in phase I and ECMO, phase II) were comparable in severity of illness and mechanical ventilator support. The overall survival of ECMO-treated infants was 97% (28 of 29) compared with 60% (6 of 10) in the CMT group (P< .05).
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Cited by
Peek, G. J., Mugford, M., Tiruvoipati, R., Wilson, A., Allen, E., Thalanany, M. M., Hibbert, C. L., Truesdale, A., Clemens, F., Cooper, N., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61069-2 · Cited by 3,395
UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation
(1996) · The Lancet · doi:10.1016/s0140-6736(96)04100-1 · Cited by 734
Brogan, T. V., Thiagarajan, R. R., Rycus, P. T., Bartlett, R. H., & Bratton, S. L. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1661-7 · Cited by 441
Extracorporeal Life Support: The University of Michigan Experience
Bartlett, R. H., Roloff, D. W., Custer, J. R., Younger, J. G., & Hirschl, R. B. (2000) · JAMA · doi:10.1001/jama.283.7.904 · Cited by 351
Snowdon, C., Garcia, J., & Elbourne, D. (1997) · Social Science & Medicine · doi:10.1016/s0277-9536(97)00063-4 · Cited by 296
Metadata
- Authors
- O'Rourke, P. P., Crone, R. K., Vacanti, J. P., Ware, J. H., Lillehei, C. W., Parad, R. B., & Epstein, M. F.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1989-12-01
- Volume
- 84
- Issue
- 6
- Pages
- 957-963
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2157030563
- Cited by
- 493
- References
- 0
- FWCI
- 30.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Extracorporeal Membrane Oxygenation and Conventional Medical Therapy in Neonates With Persistent Pulmonary Hypertension of the Newborn: A Prospective Randomized Study. https://app.cochat.ai/papers/10.1542/peds.84.6.957
- The paper
- O'Rourke, P. P., Crone, R. K., Vacanti, J. P., Ware, J. H., Lillehei, C. W., Parad, R. B., & Epstein, M. F. (1989). Extracorporeal Membrane Oxygenation and Conventional Medical Therapy in Neonates With Persistent Pulmonary Hypertension of the Newborn: A Prospective Randomized Study. Pediatrics. https://doi.org/10.1542/peds.84.6.957
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
