The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Procalcitonin is a good tool to guide duration of antibiotic therapy in patients with severe acute pancreatitis. A randomized prospective single-center controlled trial.
Abstract
Objective To investigate the clinical usefulness of procalcitonin (PCT) for guiding duration of antibiotic therapy in patients with severe acute pancreatitis (SAP). Methods A total of 71 patients with confirmed severe acute pancreatitis from March 2009 to September 2011 in the Department of Critical Care Medicine of Huizhou Municipal Central Hospital, Guangdong, China were enrolled in this study. Procalcitonin was measured daily by a semi-quantitative immunoassay in the study group. Patients were randomly assigned into 2 groups including a PCT-guided group (study group) and a prophylactic antibiotic therapy (control group). Antibiotic therapy in the study group was not applied until clinical signs and symptoms of infection appeared (PCT value was >0.5ng/ml). We discontinued the antibiotic therapy if clinical signs and symptoms of infection improved and PCT was Results In the study group (35 patients), the duration of antibiotic therapy and hospitalization was significantly shorter than the control group (36 patients) (10.89+/-2.85 versus 16.06+/-2.48 days, p Conclusion Procalcitonin is a helpful and safe tool for guiding duration of antibiotic treatment in patients with severe acute pancreatitis.
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“We identified direct evidence from 14 RCTs (n = 4,499 patients) that assessed use of procalcitonin to guide antimicrobial treatment duration in patients with sepsis (two trials included critically ill patients in general) (308-321).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [317]
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Hochreiter, M., Köhler, T., Schweiger, A. M., Keck, F. S., Bein, B., von Spiegel, T., & Schroeder, S. (2009) · Critical Care · doi:10.1186/cc7903 · Cited by 315
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082
For the sepsis in resource-limited settings–expert consensus recommendations group of the European Society of Intensive Care Medicine (ESICM) and the Mahidol-Oxford Research Unit (MORU) in Bangkok, T., Thwaites, C. L., Lundeg, G., & Dondorp, A. M. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4415-3 · Cited by 35
Metadata
- Authors
- Qu, R., Ji, Y., Ling, Y., Ye, C.-Y., Yang, S.-M., Liu, Y.-Y., Yang, R.-Y., Luo, Y.-F., & Guo, Z.
- Affiliations
- Huizhou Central People's Hospital (CN)
- ORCID
- Ji, Yan
- Venue
- Saudi Medical Journal
- Publisher
- Armed Forces Medical Services
- Published
- 2012-04-01
- Volume
- 33
- Issue
- 4
- Pages
- 382-387
- ISSN
- 0379-5284 (ISSN-L)
- 1658-3175
- OpenAlex
- W1667825434
- Cited by
- 46
- References
- 1
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Saudi Medical Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- procalcitonin, severe acute pancreatitis, antibiotic duration, antibiotic stewardship, antibiotic prophylaxis, infection biomarkers, length of hospital stay, hospital costs
- MeSH terms
- Acute Disease, Anti-Bacterial Agents, Calcitonin, Humans, Pancreatitis, Prospective Studies, Protein Precursors, Calcitonin Gene-Related Peptide
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