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Cited by 150Magnesium Alloys: Properties and ApplicationsTitanium Alloys Microstructure and PropertiesMagnesium in Health and Disease

Magnesium-based biodegradable alloys: Degradation, application, and alloying elements

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Pogorielov, Maksym, Husak, Eugenia, Solodivnik, Alexandr, Zhdanov, Sergii·2017·Interventional Medicine and Applied Science
DOI 10.1556/1646.9.2017.1.04PMC PMC5598119
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Abstract

In recent years, the paradigm about the metal with improved corrosion resistance for application in surgery and orthopedy was broken. The new class of biodegradable metal emerges as an alternative for biomedical implants. These metals corrode gradually with an appropriate host response and release of corrosion products. And it is absolutely necessary to use essential metals metabolized by hosting organism with local and general nontoxic effect. Magnesium serves this aim best; it plays the essential role in body metabolism and should be completely excreted within a few days after degradation. This review summarizes data from Mg discovery and its first experimental and clinical application of modern concept of Mg alloy development. We focused on biodegradable metal application in general surgery and orthopedic practice and showed the advantages and disadvantages Mg alloys offer. We focused on methods of in vitro and in vivo investigation of degradable Mg alloys and correlation between these methods. Based on the observed data, a better way for new alloy pre-clinical investigation is suggested. This review analyzes possible alloying elements that improve corrosion rate, mechanical properties, and gives the appropriate host response.

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  • The clinical application of magnesium is limited due to the difficulty in controlling the timing of degradation in physiological environments.

    “However, the clinical application of magnesium is limited due to its rapid corrosion and the consequent rapid deterioration of mechanical properties, as well as the difficulty in controlling the timing of degradation in physiological environments [33,35].”

    From Functional Surface Modification of Magnesium Implant by Drug-Loaded Biodegradable Polymer Coating (2026) · cites this paper as [35]

  • The clinical application of magnesium is limited due to its rapid corrosion and the consequent rapid deterioration of mechanical properties.

    “However, the clinical application of magnesium is limited due to its rapid corrosion and the consequent rapid deterioration of mechanical properties, as well as the difficulty in controlling the timing of degradation in physiological environments [33,35].”

    From Functional Surface Modification of Magnesium Implant by Drug-Loaded Biodegradable Polymer Coating (2026) · cites this paper as [35]

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Cited by

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Authors
Pogorielov, M., Husak, E., Solodivnik, A., & Zhdanov, S.
Affiliations
Sumy State University (UA)
Corresponding author
Pogorielov, Maksym
ORCID
Pogorielov, Maksym
Venue
Interventional Medicine and Applied Science
Publisher
Akademiai Kiado Zrt.
Published
2017-03
Volume
9
Issue
1
Pages
27-38
ISSN
  • 2061-1617 (ISSN-L)
  • 2061-5094
DOI
10.1556/1646.9.2017.1.04
PMC
PMC5598119
OpenAlex
W2599112746
Cited by
150
References
1
Citations by year
2026: 16 · 2025: 15 · 2024: 20 · 2023: 11 · 2022: 16 · 2021: 26 · 2020: 17 · 2019: 12 · 2018: 15 · 2017: 2
FWCI
0.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Interventional Medicine and Applied Science (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
  • Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Keywords
magnesium alloys, biodegradable metals, biodegradable implants, corrosion behavior, alloying elements, corrosion products, host response, orthopedic implants, surgical implants, mechanical properties, preclinical evaluation

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