The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Parkinson’s Disease: Pathogenesis and Clinical Aspects
Abstract
Metodología: Se empleó el modelo de reserpina como inductor de sintomatología parkinsoniana para poder evaluar los posibles efectos antiparkinsonianos del extracto de Nertera granadensis, así como los efectos de la asociación del extracto con levodopa/carbidopa.Además, se evaluó la posible actividad antioxidante del extracto por medio del ensayo de TBARs.Resultados: En el modelo de reserpina la dosis de 300 mg/kg del extracto etanólico de Nertera granadensis presentó tendencia a revertir la hipocinesia.La asociación de esta dosis con levodopa/carbidopa presentó mejor respuesta comparada con el tratamiento individual del extracto.En la evaluación ex vivo de la actividad antioxidante, no se encontraron diferencias significativas entre los tratamientos, el control, ni el blanco.Conclusiones: El extracto etanólico de Nertera granadensis no presentó efectos antiparkinsonianos significativos.Sin embargo, cuando se asocia con levodopacarbidopa se observa una tendencia a mejorar el desempeño del animal.
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Cites
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13 reasons why the brain is susceptible to oxidative stress
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Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
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A rotarod test for evaluation of motor skill learning
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Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors
Emamzadeh, F. N., & Surguchov, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00612 · Cited by 568
Protective and toxic roles of dopamine in Parkinson's disease
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Striatal dopamine mediates hallucination-like perception in mice
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Cited by
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Armstrong, M. J., & Okun, M. S. (2020) · JAMA · doi:10.1001/jama.2019.22360 · Cited by 2,924
Watanabe, H., Dijkstra, J. M., & Nagatsu, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042009 · Cited by 48
The Role of miR-128 in Neurodegenerative Diseases
Lanza, M., Cuzzocrea, S., Oddo, S., Esposito, E., & Casili, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076024 · Cited by 27
Post-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo Hypothesis
Mysiris, D. S., Vavougios, G. D., Karamichali, E., Papoutsopoulou, S., Stavrou, V. T., Papayianni, E., Boutlas, S., Mavridis, T., Foka, P., Zarogiannis, S. G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179739 · Cited by 25
Small Extracellular Vesicles’ miRNAs: Biomarkers and Therapeutics for Neurodegenerative Diseases
Lim, W. Q., Michelle Luk, K. H., Lee, K. Y., Nurul, N., Loh, S. J., Yeow, Z. X., Wong, Q. X., Daniel Looi, Q. H., Chong, P. P., How, C. W., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041216 · Cited by 25
Metadata
- Venue
- Codon Publications eBooks
- Publisher
- Codon Publications
- Published
- 2018-12-22
- OpenAlex
- W3042654062
- Cited by
- 294
- References
- 40
- FWCI
- 38.67
- Type
- book
- Language
- en
- Open access
- closed
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