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Overview of Carboxylesterases and Their Role in the Metabolism of Insecticides
Open accessAbstract
Carboxylesterases hydrolyze numerous endogenous and exogenous ester-containing compounds.They play a role in the detoxification of many agrochemicals including pyrethroids, organophosphates, and carbamates.Research on these enzymes is still developing and there are several topics that should be addressed to further investigations in this area.This paper focuses on a number of these issues including enzyme nomenclature, catalytic mechanism, substrate specificity, agrochemical metabolism, role in insecticide resistance and environmental significance.It is expected that carboxylesterase research will increase with specific emphasis on isozyme and substrate identification.Future research directions are discussed and the current state of the field is evaluated.
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Citations
Cites
Acetylcholinesterase: Enzyme structure, reaction dynamics, and virtual transition states
Quinn, D. M. (1987) · Chemical Reviews · doi:10.1021/cr00081a005 · Cited by 1,072
Cited by
Senthil-Nathan, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01591 · Cited by 266
Montella, I. R., Schama, R., & Valle, D. (2012) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762012000400001 · Cited by 253
Metadata
- Authors
- Wheelock, C. E., Shan, G., & Ottea, J.
- Venue
- Journal of Pesticide Science
- Publisher
- Pesticide Science Society of Japan
- Published
- 2005
- Volume
- 30
- Issue
- 2
- Pages
- 75-83
- ISSN
- 0385-1559 (ISSN-L)
- 1348-589X
- 1349-0923
- OpenAlex
- W2094724812
- Cited by
- 308
- References
- 1
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wheelock, C. E., Shan, G., & Ottea, J. (2005). Overview of Carboxylesterases and Their Role in the Metabolism of Insecticides. Journal of Pesticide Science. https://doi.org/10.1584/jpestics.30.75
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